Related Experiment Video

Updated: Sep 27, 2025

HPLC-based Assay to Monitor Extracellular Nucleotide/Nucleoside Metabolism in Human Chronic Lymphocytic Leukemia Cells
11:29

HPLC-based Assay to Monitor Extracellular Nucleotide/Nucleoside Metabolism in Human Chronic Lymphocytic Leukemia Cells

Published on: July 20, 2016

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Small nucleolar RNA is potential as a novel player in leukemogenesis and clinical application

Li-Min Lin1, Qi Pan1, Yu-Meng Sun1

  • 1MOE Key Laboratory of Gene Function and Regulation, State Key Laboratory for Biocontrol, School of Life Sciences, Sun Yat-Sen University, Guangzhou, Guangdong 510275, China.

Blood Science (Baltimore, Md.)
|April 11, 2022
PubMed

Insights

Small nuclear RNAs (snoRNAs) are crucial in leukemia development and progression. Dysregulated snoRNAs show potential as diagnostic markers and therapeutic targets for leukemia treatment.

Area of Science:

  • Molecular Biology
  • Oncology
  • Genetics

Background:

  • Leukemogenesis mechanisms remain unclear, hindering leukemia diagnosis, prognosis, and treatment.
  • Small nuclear RNAs (snoRNAs) are implicated in ribosome biogenesis and RNA modification.
  • Orphan snoRNAs, lacking predictable targets, are found in various subcellular locations with diverse functions.

Purpose of the Study:

  • To review the expression profiles and functions of snoRNAs, especially orphan snoRNAs, in leukemia.
  • To explore the potential of snoRNAs as diagnostic and prognostic markers for leukemia.
  • To discuss snoRNAs as potential therapeutic targets in leukemia treatment.

Main Methods:

  • Analysis of high-throughput technology data to reveal snoRNA expression profiles in leukemia.
  • Review of existing literature on snoRNA functions in cellular processes relevant to leukemia.
  • Investigation of the role of deregulated snoRNAs in leukemic cell behavior and drug resistance.

Main Results:

  • SnoRNA expression profiles are altered in leukemia.
  • Deregulated snoRNAs can influence cell cycle, differentiation, proliferation, and apoptosis in leukemic cells.
  • Some snoRNAs contribute to drug resistance during leukemia therapy.

Conclusions:

  • Dysregulated snoRNAs are promising diagnostic and prognostic markers for leukemia.
  • Orphan snoRNAs play diverse roles in leukemia and warrant further investigation.
  • SnoRNAs represent potential therapeutic targets for novel leukemia treatments.
Keywords:
2′-O-methylationBiomarkersDrug resistanceLeukemiaTargeted therapysnoRNA

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