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Updated: Sep 27, 2025

Screening for Functional Non-coding Genetic Variants Using Electrophoretic Mobility Shift Assay EMSA and DNA-affinity Precipitation Assay DAPA
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Expanding DNA database effectiveness.

Ray A Wickenheiser1

  • 1New York State Police Crime Laboratory System, Albany, NY, USA.

Forensic Science International. Synergy
|April 11, 2022
PubMed
Summary

Expanding DNA databases, through increased offenses or universal adoption, enhances crime-solving potential. Scientific methods like familial searching and genetic genealogy leverage DNA sharing to identify relatives and solve cases, including unidentified human remains.

Keywords:
DNA databaseEnhanced DNA Indirect matchingForensic DNAForensic genetic genealogyGenetic genealogyIndirect comparisonInvestigative genetic genealogyKinship analysisMitochondrial DNA searchingUnidentified human remainsUniversal DNA DatabaseX Chromosome searchingY-STR Searching

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Area of Science:

  • Forensic Science
  • Genetics
  • Criminology

Background:

  • DNA databases are crucial for developing investigative leads in criminal investigations.
  • The effectiveness of DNA databases is directly proportional to their size and scope.

Purpose of the Study:

  • To explore strategies for expanding DNA database size, both physically and theoretically.
  • To introduce novel scientific methods for increasing the investigative power of DNA databases.

Main Methods:

  • Physical expansion via increased qualifying offenses, arrestee inclusion, or universal database implementation.
  • Theoretical expansion using indirect matching strategies: Partial Matching, Familial Searching, and Investigative Genetic Genealogy (IGG).
  • Introduction of new search key strategies utilizing shared DNA regions (Y-STR, mtDNA, X Chromosome) for kinship evaluation and unidentified human remains (UHRs) analysis.

Main Results:

  • Larger DNA databases increase the probability of solving crimes.
  • Familial searching and IGG effectively utilize genetic relatedness for investigations.
  • Novel search key strategies offer new avenues for identifying potential relatives and matching UHRs.

Conclusions:

  • Strategic expansion of DNA databases, both physically and theoretically, is key to improving criminal investigations.
  • Innovative genetic searching techniques enhance the capacity to solve complex cases and identify unknown individuals.