Related Experiment Video
Updated: Sep 27, 2025

Author Spotlight: Studying Host-Virus Interactions with Pseudotyped Viruses
Published on: November 21, 2023
COVID-19 Vaccine Hesitancy and Refusal:: The Same But Different?
1Division of Infectious Disease, Department of Pediatrics, Nemours Children's Hospital-Delaware.
Insights
Pediatric providers face COVID-19 vaccine hesitancy, similar to routine vaccines but with unique fears. Understanding these reasons is key to developing effective strategies for increasing pediatric COVID-19 vaccination rates.
Area of Science:
- Pediatrics
- Public Health
- Infectious Diseases
Background:
- Pediatric providers routinely manage vaccine hesitancy for childhood immunizations.
- The COVID-19 pandemic introduced new challenges, including hesitancy and refusal of COVID-19 vaccines among children and parents.
- Concerns regarding COVID-19 vaccines share similarities with routine vaccines but also present unique issues.
Purpose of the Study:
- To identify and understand the specific reasons behind COVID-19 vaccine hesitancy in pediatric populations.
- To inform the development of targeted strategies for pediatric providers to address parental and patient concerns about COVID-19 vaccination.
Main Methods:
- This study involved a review of existing literature and clinical observations regarding vaccine hesitancy.
- Analysis focused on common and unique factors contributing to hesitancy for both routine and COVID-19 vaccines in children.
- Qualitative and quantitative data on parental concerns were synthesized.
Main Results:
- COVID-19 vaccine hesitancy is driven by fears of both known and unknown side effects.
- Unique concerns related to the novel nature of the virus and vaccine technology contribute to hesitancy.
- Similarities exist with routine vaccine hesitancy, including misinformation and distrust.
Conclusions:
- Addressing pediatric COVID-19 vaccine hesitancy requires acknowledging both shared and unique concerns.
- Developing effective communication strategies tailored to these specific fears is crucial for improving vaccine uptake.
- Pediatric providers need resources and approaches to effectively counsel families and promote COVID-19 vaccination.
Abstract:
Pediatric providers deal with vaccine hesitancy and vaccine refusal for routine childhood vaccinations on a regular basis. However, the COVID-19 pandemic has brought challenges for pediatricians including COVID-19 vaccine hesitancy and refusal. Some of the issues surrounding COVID-19 vaccine hesitancy are similar to those associated with routine vaccines, however some are unique to COVID-19. Much of COVID-19 vaccine hesitancy has been because of both the fear of the known and unknown. Identifying these issues and reasons for hesitancy is important to devising strategies and approaches pediatric providers can use to address patient and parent concerns, and hopefully convince them to vaccinate against COVID-19.
Related Concept Videos
Vaccinations
Social Proof
Bias in Epidemiological Studies
Cancer Vaccines
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
Hazard Ratio
For example, in a clinical trial...
The Availability Heuristic

