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Correlation Between TIMI Risk Score and the Number of Vessels Involved in the Angiographic Study; a Cross-sectional
Mohammad Hasan Namazi1, Seyede Salimeh Mazloomi1, Mohammad Kalate Aghamohammadi2
1Department of Cardiology, Moddares Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Insights
The Thrombolysis in Myocardial Infarction (TIMI) score directly correlates with the number of diseased coronary vessels in patients with Unstable Angina or NSTEMI. Higher TIMI scores indicate a greater likelihood of multi-vessel coronary artery disease.
Area of Science:
- Cardiology
- Vascular Medicine
- Diagnostic Tools
Background:
- The Thrombolysis in Myocardial Infarction (TIMI) score is established for assessing vascular disease severity.
- Unstable Angina (UA) and Non-ST Elevation Myocardial Infarction (NSTEMI) are critical cardiovascular conditions requiring accurate prognostic tools.
Purpose of the Study:
- To investigate the correlation between the TIMI score and the extent of coronary artery disease (number of involved vessels).
- To assess the predictive value of the TIMI score in patients presenting with UA or NSTEMI.
Main Methods:
- Prospective, cross-sectional study design.
- Inclusion of 297 patients diagnosed with UA or NSTEMI.
- Correlation analysis between TIMI scores and angiographically determined number of diseased coronary vessels.
Main Results:
- A significant positive correlation was observed between TIMI scores and the number of coronary vessels involved.
- Patients with higher TIMI scores (5-7) had a substantially greater likelihood of three-vessel disease compared to those with lower scores (0-2 or 3-4).
- Elevated TIMI scores (3-4 and 5-7) were also associated with an increased likelihood of two-vessel disease compared to the lowest score group (0-2).
Conclusions:
- The TIMI score serves as a valuable indicator of coronary artery disease burden in patients with UA and NSTEMI.
- A direct and statistically significant relationship exists between the TIMI score and the number of coronary vessels affected.
- This finding supports the utility of the TIMI score in risk stratification and management decisions for these patients.
Introduction:
TIMI (Thrombolysis in Myocardial Infarction) score is a model for predicting the severity of vascular diseases. This study aimed to evaluate the correlation between this score and the number of vessels involved in patients with Unstable Angina (UA) or Non-ST Elevation Myocardial Infarction (NSTEMI).
Methods:
This prospective cross-sectional study was designed to evaluate the correlation between TIMI score, and the number of vessels involved in the angiographic study of NSTEMI and UA patients presenting to emergency department.
Results:
297 patients with the mean age of 62.16±36.59 years were entered (58.2% male; 193 (65%) UA and 104 (35%) NSTEMI). The Mean TIMI score among patients was 3.21±1.55. Based on the TIMI score, patients were categorized into 3 groups. 105 (35.35%) patients had a TIMI score of 0 to 2, 120 (40.40%) had a score of 3 to 4, and 72 (24.24%) had a score of 5 to 7. Patients with a TIMI score of 5 to 7 had a greater likelihood of three-vessel coronary artery disease compared to patients with a TIMI score of 3 to 4 (OR: 5.34, 95% CI: 2.64 to 10.80; p < 0.0001) or those with a TIMI score of 0 to 2. (OR: 29.45, 95% CI: 12.87 to 67.37; p < 0.0001). Two-vessel coronary artery disease was more likely to be found in patients with a TIMI score of 3 to 4 or those with a score of 5 to 7 compared to patients with a TIMI score of 0 to 2 (OR: 3.69, 95% CI: 1.60 to 8.51; p <0.0001 and OR: 2.67, 95% CI: 1.04 to 6.82; p = 0.04, respectively).
Conclusion:
There is a direct and significant correlation between TIMI score and the number of coronary vessels involved in patients presenting to emergency department following UA or NSTEMI.
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