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Updated: Sep 27, 2025
Author Spotlight: Investigating the Pathophysiology of Eosinophilic Esophagitis
Published on: May 10, 2024
Correlation Between the Transient Elevation of Peripheral Eosinophil Count During Radiotherapy and Acute Diarrhea
Takako Kobayashi1, Fumiaki Isohashi1, Daisuke Eino1
1Department of Radiation Oncology, Osaka University Graduate School of Medicine, Suita, Japan.
Background/Aim:
This study aimed to evaluate the association between the change in peripheral eosinophil count during postoperative pelvic radiotherapy and gastrointestinal (GI) toxicities in patients with cervical cancer.
Patients And Methods:
The medical records of 163 patients with cervical cancer who underwent postoperative concurrent chemoradiotherapy between 2000 and 2016 were analyzed.
Results:
Among the peripheral blood cell counts, transient elevation of the eosinophil count was observed during radiotherapy. Of the 163 patients, 117 developed grade ≥2 diarrhea during radiotherapy, and 25 patients developed grade ≥2 late GI toxicities. In multivariate analysis, the maximum eosinophil count and age emerged as independent predictors of grade ≥2 acute diarrhea during radiotherapy, while bowel bag V and age were predictive of grade ≥2 late GI toxicities.
Conclusion:
Early detection of transient elevation of eosinophil may facilitate early treatment of acute diarrhea during radiotherapy.
