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Updated: Sep 27, 2025
The Establishment of a Lung Colonization Assay for Circulating Tumor Cell Visualization in Lung Tissues
Published on: June 16, 2018
Vein-first Lobectomy for Lung Cancer Assessed According to the Status of Clustered Circulating Tumour Cells
Noriyoshi Sawabata1,2, Shigeru Nakane2, Daiki Yoshikawa1
1Department of Thoracic and Cardio-Vasucilar Surgery, Nara Medical University, Kashihara, Japan.
Background/Aim:
Vein-first lobectomy (VFL) in lung cancer might reduce shedding of circulating tumour cells (CTCs). This study assessed the clinical significance of VFL.
Patients And Methods:
Lung cancer patients undergoing lobectomy and CTC testing were evaluated. The primary evaluation item was postoperative clustered CTC detection, and the secondary outcome measures were the 2-year overall survival and recurrence-free survival rates according to the status of VFL and postoperative clustered CTC.
Results:
Eighty-six patients with similar backgrounds, except for lobe resection and pulmonary vein dissection time, showed postoperative clustered CTC identification rates of 43.8% and 37.9% in the VFL group (n=57) and no-VFL group (n=29), respectively. However, prognosis was not significantly different, although the presence of clustered CTC after surgery was a predictor of recurrence.
Conclusion:
The status of postoperative clustered CTC was similar regardless of VFL or not, although the detection of clustered CTC was a predictor of recurrence.
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