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Endoscopic grading systems for nasal polyps: are we comparing apples to oranges?
P G Djupesland1, S Reitsma2, C Hopkins3
1Optinose AS, Oslo Science Park, Oslo, Norway.
Rhinology
|April 11, 2022
Summary
Nasal polyp grading systems lack consensus, hindering clinical trial data comparison. Reporting baseline polyp grades and changes over time can improve interpretability for chronic rhinosinusitis with nasal polyps treatments.
Area of Science:
- Otolaryngology
- Clinical Trials
- Rhinology
Background:
- Endoscopic grading of nasal polyps (NP) is crucial for chronic rhinosinusitis with nasal polyps (CRSwNP) clinical trials.
- Current NP grading systems lack standardization, impeding cross-trial data interpretation.
- Various scales are used, leading to inconsistencies in evaluating treatment efficacy.
Approach:
- This review analyzes NP grading systems employed in registration trials for approved NP treatments.
- The study highlights fundamental differences in these grading methodologies.
- The focus is on identifying limitations that affect quantitative outcome comparisons.
Key Points:
- Discrepancies in NP grading systems lead to inaccurate and potentially misleading cross-trial comparisons.
- A universal grading system for nasal polyps has not yet been established.
- Differences in scales complicate the assessment of treatment effectiveness for CRSwNP.
Conclusions:
- Standardized reporting of baseline polyp burden and longitudinal changes by baseline grade is recommended.
- This approach can enhance the interpretability of outcomes in CRSwNP trials.
- Improved reporting methods may reduce inaccuracies in therapeutic decision-making and cross-trial analysis.
