Related Experiment Video

Updated: Sep 27, 2025

Gene Regulation and Targeted Therapy in Gastric Cancer Peritoneal Metastasis: Radiological Findings from Dual Energy CT and PET/CT
10:28

Gene Regulation and Targeted Therapy in Gastric Cancer Peritoneal Metastasis: Radiological Findings from Dual Energy CT and PET/CT

Published on: January 22, 2018

11.2K

Role of sacituzumab govitecan in solid tumors

Sindhusha Veeraballi1, Zaineb Khawar2, Hafiz Muhammad Aslam3

  • 1Department of Medical Education, 22423Saint Michael's Medical Center, New York Medical College, New Jersey, United States.

Journal of Oncology Pharmacy Practice : Official Publication of the International Society of Oncology Pharmacy Practitioners
|April 11, 2022
PubMed
Abstract

Insights

Sacituzumab govitecan (SG) is an antibody-drug conjugate showing improved survival and quality of life in cancer patients. Ongoing trials explore its use in various solid tumors and treatment settings.

Area of Science:

  • Oncology
  • Pharmacology
  • Cancer Therapeutics

Background:

  • Antibody-drug conjugates (ADCs) represent an emerging class of targeted cancer therapies.
  • Sacituzumab govitecan (SG) is an FDA-approved ADC for metastatic triple-negative breast cancer (mTNBC) after prior systemic therapies.
  • The efficacy of SG beyond breast cancer warrants further investigation.

Purpose of the Study:

  • To review the pharmacological properties and toxicity of sacituzumab govitecan.
  • To evaluate the efficacy of SG in solid tumors beyond breast cancer.
  • To explore potential future applications and ongoing clinical trials of SG.

Main Methods:

  • Literature search of MEDLINE/PubMed and ClinicalTrials.gov (January 2015 - July 2021).
  • Keywords: sacituzumab govitecan, solid tumors.
  • Review of pharmacokinetic, pharmacodynamic, and safety data, alongside clinical trial information.

Main Results:

  • Sacituzumab govitecan demonstrates improved progression-free survival (PFS) and overall survival (OS).
  • SG significantly enhances health-related quality of life (HRQoL) in patients.
  • The agent maintains a favorable safety profile.

Conclusions:

  • Sacituzumab govitecan represents a significant advancement in cancer therapy.
  • Ongoing trials are investigating SG in neoadjuvant/adjuvant settings for TNBC and in combination with immunotherapy.
  • Further research will elucidate SG's potential across a broader spectrum of solid tumors.
Keywords:
Sacituzumab govitecansolid tumors

More Related Videos

Tracking Bispecific Antibody-Induced T Cell Trafficking Using Luciferase-Transduced Human T Cells10:19

Tracking Bispecific Antibody-Induced T Cell Trafficking Using Luciferase-Transduced Human T Cells

Published on: May 12, 2023

1.3K
A GPC3-targeting Bispecific Antibody, GPC3-S-Fab, with Potent Cytotoxicity11:13

A GPC3-targeting Bispecific Antibody, GPC3-S-Fab, with Potent Cytotoxicity

Published on: July 12, 2018

8.8K

Related Concept Videos

Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
7.9K
Tumor Immunotherapy01:27

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
691
Cancer Vaccines01:30

Cancer Vaccines

Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
535
Treatment Resistant Cancers02:56

Treatment Resistant Cancers

Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
3.4K
Cancer Therapies02:49

Cancer Therapies

Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
8.0K