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Robotic CyberKnife radiosurgery for small choroidal melanomas.
Valerie Schmelter1, Theresa Hofmann2, Frederick Schneider3
1Department of Ophthalmology, University Hospital, LMU Munich.
Melanoma Research
|April 11, 2022
Summary
CyberKnife radiosurgery effectively treats small choroidal melanomas, achieving high local tumor control. Key factors for success include prescription dose and precise treatment planning.
Area of Science:
- Ophthalmology
- Radiation Oncology
- Oncology
Background:
- Plaque brachytherapy is standard for small choroidal melanomas.
- Limited data exists on stereotactic radiosurgery outcomes for this condition.
Purpose of the Study:
- Evaluate CyberKnife radiosurgery for small choroidal melanomas.
- Identify risk factors influencing local tumor control and survival.
Main Methods:
- Retrospective review of 188 patients with choroidal melanoma (max height 4 mm) treated with CyberKnife.
- Analysis of demographic data, tumor dimensions, complications, metastasis, and survival.
Main Results:
- High survival rate (94.7%) and eye retention (88.3%) observed.
- Local control achieved in 91.6% of patients receiving ≥21 Gy.
- Prescription dose, MRI use, and target delineation impacted local control.
Conclusions:
- CyberKnife radiosurgery is a viable outpatient treatment for small choroidal melanomas.
- Identified risk factors can optimize treatment regimens for improved local control.
