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Related Concept Videos

Cytotoxic T Cells-mediated Immune Response01:27

Cytotoxic T Cells-mediated Immune Response

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Cytotoxic T cells are a vital component of the immune system. They have the remarkable ability to identify and target antigens on infected or abnormal cells. These antigens often originate from intracellular pathogens such as viruses or abnormal proteins cancer cells produce.
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...
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Tumor Immunotherapy01:27

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Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
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Updated: Sep 27, 2025

Flow Cytometry-based Assay for the Monitoring of NK Cell Functions
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An NK-cell Therapy for CD30+ Lymphomas

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    Summary
    This summary is machine-generated.

    Natural killer cells from cord blood combined with AFM13 demonstrated effectiveness in patients with relapsed or refractory CD30-positive lymphomas. This innovative therapy was well-tolerated and led to complete responses in clinical trials.

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    Area of Science:

    • Immunotherapy
    • Hematology
    • Oncology

    Background:

    • Relapsed/refractory CD30+ lymphomas present a significant unmet medical need.
    • Existing treatments for these lymphomas have limitations in efficacy and tolerability.

    Purpose of the Study:

    • To evaluate the safety and efficacy of cord blood-derived natural killer (NK) cells in combination with AFM13, a bispecific antibody.
    • To assess treatment outcomes in patients with relapsed/refractory CD30+ lymphomas.

    Main Methods:

    • Phase I/II clinical trial.
    • Treatment involved cord blood-derived NK cells complexed with the bispecific antibody AFM13.
    • Patient population: adults with relapsed/refractory CD30+ lymphomas.

    Main Results:

    • Preliminary results indicate significant efficacy.
    • Complete responses were observed in treated patients.
    • The combination therapy was extremely well tolerated, with a favorable safety profile.

    Conclusions:

    • Cord blood-derived NK cells combined with AFM13 show promising efficacy for relapsed/refractory CD30+ lymphomas.
    • This therapeutic approach offers a potentially safe and effective treatment option.
    • Further investigation in larger trials is warranted.