Amphiphilic Indoles as Efficient Phase-Transfer Catalysts for Bromination in Water
Qingyu Zhang1, Yongyuan Xu1, Xiaochen Liang1
1School of Science and Engineering, The Chinese University of Hong Kong, Shenzhen, 518172, Guangdong, P. R. China.
Abstract:
Brominated compounds are important, but they are usually prepared in organic solvents. Here, efficient amphiphilic indole-based phase-transfer organocatalysts were developed for environmentally benign bromination reactions in water. As test reactions, hydroxybromination of olefins and aromatic bromination could be conducted in a greener and more sustainable manner compared with methods using organic solvents, producing the corresponding bromides in good yields. Some pure products could be obtained without column chromatography.
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