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Hodgkin disease: malignancy, inflammation and abnormal immunity
Leukemia Research
|January 1, 1986
Abstract:
The effect of Hodgkin disease cells on the surrounding environment is complex. In the light of recent findings on growth factors and oncogenes a hypothesis on Hodgkin disease is presented. The interrelation of three main features of Hodgkin disease: malignancy, inflammation and abnormal immunity may be explained by the local secretion of platelet-derived growth factor like substances and interleukin-1 like substances by malignant Hodgkin disease cells.