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T-cell-redirecting bispecific antibodies in multiple myeloma: a revolution?

Philippe Moreau1,2, Cyrille Touzeau1,2

  • 1Department of Hematology, University Hospital Hôtel-Dieu, Nantes, France; and.

Blood
|April 11, 2022
PubMed

Bispecific antibodies are monoclonal antibodies targeting both a surface molecule on the malignant plasma cells and CD3 on T cells, leading to tumor cell death by activated T cells. Bispecific antibodies targeting B-cell maturation antigen, GPRC5D or FcRH5, demonstrated promising efficacy with favorable safety profile in patients with triple-class refractory multiple myeloma. This novel immunotherapeutic modality will likely change the treatment paradigm in the coming years.

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