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Adding a New Dimension to the Amorphous Solid Dispersion Phase Diagram: Studying Dissolution Kinetics of Crystalline

Vanessa K Seiler1, Frank Theil1, Norbert Nagel1

  • 1AbbVie Deutschland GmbH & Co. KG, Knollstraße, 67061 Ludwigshafen, Germany.

Journal of Pharmaceutical Sciences
|April 11, 2022
PubMed

Keywords:
AcetaminophenAmorphous solid dispersionsDSCDissolution kineticsHot melt extrusionIndomethacinParticle size effectPhase diagramProcess operating design spaceTemperature dependent XRPD

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