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Updated: Sep 27, 2025

A Customizable Approach for the Enzymatic Production and Purification of Diterpenoid Natural Products
Published on: October 4, 2019
Meroterpenoids containing benzopyran or benzofuran motif from Ganoderma cochlear
Fu-Ying Qin1, Dai-Wei Wang1, Te Xu1
1Institute for Inheritance-Based Innovation of Chinese Medicine, School of Pharmaceutical Sciences, Health Science Center, Shenzhen University, Shenzhen, 518060, People's Republic of China.
Abstract:
Five undescribed benzopyran containing meroterpenoids, ganodercins Q-U, two undescribed benzofuran containing meroterpenoids, ganodercins V and W, and two known meroterpenoids were isolated from Ganoderma cochlear. Their structures were elucidated by using HRESIMS, NMR spectroscopy and computational methods. The results of biochemical studies using a palmitic acid (PA) induced insulin resistance (IR) model show that (-)-ganodercin Q, (+)-ganodercins R and W activate phospho-AKT (p-AKT) at 20 μM and improve glucose uptake in a concentration dependent manner. The results of renoprotection studies show that (+)-ganodercin S, cochlearol F, (+)- and (-)-ganodercins V reduce the expression of collagen I.
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