Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Lead intoxication.

L S Ibels, C A Pollock

    Medical Toxicology
    |November 1, 1986
    PubMed
    Summary
    This summary is machine-generated.

    Lead intoxication, or plumbism, remains a significant health concern. A calcium disodium edetate chelation test is recommended for diagnosing lead poisoning and assessing body lead stores.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Maternal L-carnitine supplementation improves glucose and lipid profiles in female offspring of dams exposed to cigarette smoke.

    Clinical and experimental pharmacology & physiology·2018
    Same author

    The DPP-4 inhibitor linagliptin and the GLP-1 receptor agonist exendin-4 improve endothelium-dependent relaxation of rat mesenteric arteries in the presence of high glucose.

    Pharmacological research·2015
    Same author

    Role of body protein as a prognostic indicator in wasting disease.

    Asia Pacific journal of clinical nutrition·2014
    Same author

    Role of the EGF receptor in PPARγ-mediated sodium and water transport in human proximal tubule cells.

    Diabetologia·2013
    Same author

    Notch mediated epithelial to mesenchymal transformation is associated with increased expression of the Snail transcription factor.

    The international journal of biochemistry & cell biology·2010
    Same author

    High glucose induced endothelial cell growth inhibition is associated with an increase in TGFbeta1 secretion and inhibition of Ras prenylation via suppression of the mevalonate pathway.

    The international journal of biochemistry & cell biology·2008
    Same journal

    Chronic low-level lead exposure. Its role in the pathogenesis of hypertension.

    Medical toxicology·1987
    Same journal

    Adverse cardiovascular effects of sulphonylurea drugs. Clinical significance.

    Medical toxicology·1987
    Same journal

    Adverse reactions with oral and parenteral gold preparations.

    Medical toxicology·1987
    Same journal

    Aetiology and treatment of neuroleptic malignant syndrome.

    Medical toxicology·1987
    Same journal

    Aspirin and Reye's syndrome. A reappraisal.

    Medical toxicology·1987
    Same journal

    Focal motor status epilepticus following treatment with azlocillin and cefotaxime.

    Medical toxicology·1987
    See all related articles

    Area of Science:

    • Environmental Health
    • Toxicology
    • Occupational Medicine

    Background:

    • Lead intoxication, or plumbism, has been recognized for millennia and remains a prevalent issue in the 20th century.
    • Children are primarily affected by pica and environmental exposure, while industrially exposed adults face significant risks.
    • Clinical features are often nonspecific and can be misdiagnosed, affecting multiple body systems including the nervous, renal, and endocrine systems.

    Purpose of the Study:

    • To highlight the persistent problem of lead intoxication and its diverse manifestations.
    • To emphasize the limitations of current diagnostic markers like blood lead concentrations and hematological parameters.
    • To present the calcium disodium edetate chelation test as a reliable method for assessing body lead stores and diagnosing lead poisoning.

    Related Experiment Videos

    Main Methods:

    • Review of historical and contemporary data on lead intoxication.
    • Analysis of diagnostic challenges due to nonspecific clinical features.
    • Description of the calcium disodium edetate chelation test protocol for diagnosis and treatment, including dosage recommendations for children and adults.
    • Inclusion of urinary lead estimations post-chelation for diagnostic confirmation.

    Main Results:

    • Blood lead concentrations are unreliable for assessing body lead stores, indicating only recent exposure.
    • Hematological parameters are more reliable than blood concentrations but still fail to predict toxicity risk.
    • Calcium disodium edetate chelation testing with 72-hour urinary lead estimations is a sensitive marker for body lead stores and intoxication.
    • Lead excretion levels >350 micrograms/72 hours suggest intoxication, especially with supporting clinical evidence.

    Conclusions:

    • Lead intoxication continues to be a public health problem requiring regular screening, particularly for industrially exposed workers.
    • The calcium disodium edetate chelation test is the recommended assessment for suspected lead intoxication.
    • Treatment involves symptomatic management and chelation therapy using calcium disodium edetate, with dimercaprol added for severe cases.