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Updated: Sep 27, 2025

Novel Diagnostics in Revision Arthroplasty: Implant Sonication and Multiplex Polymerase Chain Reaction
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Routine Laboratory Tests are not Necessary After Primary Total Joint Arthroplasty: A Prospective Study Utilizing a

Jessica L H Phillips1, Yale A Fillingham1, William F Mitchell2

  • 1Department of Orthopaedic Surgery, Thomas Jefferson University, Philadelphia, PA; Rothman Institute, Philadelphia, PA.

The Journal of Arthroplasty
|April 11, 2022
PubMed
Summary
This summary is machine-generated.

Discontinuing routine laboratory tests after total joint arthroplasty (TJA) is safe and effective. This approach did not increase 90-day complications in TJA patients, supporting its implementation.

Keywords:
complicationslaboratory testsoutcomeoutpatient total joint arthroplastytotal joint arthroplasty

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Area of Science:

  • Orthopedic Surgery
  • Clinical Medicine
  • Patient Safety

Background:

  • Routine laboratory testing post-total joint arthroplasty (TJA) lacks evidence-based support.
  • Previous studies have not prospectively evaluated the impact of discontinuing these tests.
  • This research addresses the need for evidence on optimizing TJA care pathways.

Purpose of the Study:

  • To determine if discontinuing routine laboratory tests after TJA affects 90-day complication rates.
  • To evaluate the safety and efficacy of a selective laboratory testing protocol in TJA patients.
  • To provide evidence for a revised clinical guideline for post-TJA laboratory monitoring.

Main Methods:

  • Prospective protocol change study at a high-volume orthopedic center.
  • Comparison of routine laboratory testing (control) versus algorithmic selective testing (protocol) groups.
  • Exclusion criteria applied for patients with significant comorbidities; 90-day outcomes analyzed.

Main Results:

  • No significant difference in 90-day complications between the protocol (937 patients) and control (891 patients) groups.
  • Similar rates of transfusions, electrolyte corrections, and length of stay between groups.
  • The protocol group showed more fluid boluses and home discharges, indicating no adverse impact.

Conclusions:

  • Discontinuing routine laboratory tests following TJA is safe and effective when using an algorithmic approach.
  • The revised protocol can be safely implemented for the majority of primary unilateral TJA patients.
  • This strategy optimizes resource utilization without compromising patient safety or outcomes.