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Related Concept Videos

Physiological Foundation of Stress01:24

Physiological Foundation of Stress

182
Stress triggers a coordinated physiological response involving the sympathetic nervous system (SNS) and the hypothalamic-pituitary-adrenal (HPA) axis. This dual activation ensures that the body is prepared for both immediate and prolonged stress management. The process begins with the perception of a stressor. This initial phase activates the SNS, leading to the rapid release of adrenaline (epinephrine) from the adrenal glands.
Role of the Sympathetic Nervous System
Adrenaline triggers the...
182
Stress Concentrations01:13

Stress Concentrations

332
The concept of stress concentration is crucial for understanding how materials respond under bending stresses, particularly when there are irregularities or discontinuities in the material's geometry. Normally, stress in a symmetric member subjected to pure bending is assumed to be uniformly distributed across the entire cross-section. However, this assumption does not hold when there are variations in the cross-sectional geometry or the presence of notches and holes.
The stress...
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Psychological Responses to Stress01:20

Psychological Responses to Stress

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Psychological responses to stress encompass the various cognitive and emotional reactions individuals experience when faced with challenging or threatening situations, such as a job loss. Prolonged exposure to stressors can disturb emotional balance, increasing negative emotions (e.g., anxiety and sadness) and diminishing positive emotions (e.g., joy and satisfaction). These persistent emotional shifts are associated with an increased risk of both physical illness and mental health issues, such...
132
Components of Stress01:23

Components of Stress

288
Stress analysis under multiple loading conditions is intricate, necessitating a comprehensive grasp of normal and shearing stresses. Consider a small cube at point O, subjected to stress on all six faces, visible or not. Normal stress components σx, σy, σz act perpendicularly to the x, y, and z axes. Shearing stress components τxy and τxz are exerted on faces perpendicular to these axes.
Interestingly, the hidden cube faces also experience these stresses, equal and...
288
Stress and Mental Health01:30

Stress and Mental Health

232
Chronic stress profoundly affects mental health, significantly influencing mood, behavior, and overall quality of life. Research closely links chronic stress with mental health conditions such as depression, anxiety, and substance use disorders. Ongoing exposure to stress can lead to physiological and psychological changes, initiating a cycle of emotional distress and maladaptive coping mechanisms.
Individuals with depression often experience challenges in both their personal and professional...
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Applications of Stress01:04

Applications of Stress

413
Consider a structure made of a boom and a rod designed to support a load. These two components are connected by a pin and stabilized by brackets and pins. The boom and the rod are detached from their supports to assess the different stresses imposed on this structure, and a free-body diagram is drawn. Then, all the forces applied, including the load acting on the structure, are identified. The reaction forces exerted on both the boom and the rod are computed using the equilibrium equations.
The...
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Related Experiment Video

Updated: Sep 27, 2025

A Rat Methyl-Seq Platform to Identify Epigenetic Changes Associated with Stress Exposure
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Stress and the brain transcriptome: Identifying commonalities and clusters in standardized data from published

Adrian M Stankiewicz1, Aneta Jaszczyk2, Joanna Goscik3

  • 1Department of Molecular Biology, Institute of Genetics and Animal Biotechnology, Polish Academy of Sciences, Jastrzebiec, Poland.

Progress in Neuro-Psychopharmacology & Biological Psychiatry
|April 11, 2022
PubMed
Summary

This study identifies key genes consistently affected by stress across multiple species and experimental models. Findings reveal overlaps between animal models and human post-traumatic stress disorder (PTSD), highlighting potential new research avenues.

Keywords:
BrainGlucocorticoidsPTSDResistanceSexStressTranscriptomeVulnerability

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Area of Science:

  • Neuroscience
  • Genetics
  • Molecular Biology

Background:

  • Transcriptomic analysis faces challenges like false positives and gene nomenclature changes, complicating stress response research.
  • Understanding the consistent effects of stress on the brain transcriptome is crucial for advancing neuroscience and mental health studies.

Purpose of the Study:

  • To identify the most consistent gene expression changes in the brain due to stress across diverse studies.
  • To validate the relevance of animal models for studying human stress responses, specifically post-traumatic stress disorder (PTSD).

Main Methods:

  • Meta-analysis of transcriptomic data from 79 animal studies and 3 human studies on stress and PTSD.
  • Utilized data from microarrays and RNA sequencing on over 1887 animals and 121 humans.
  • Analyzed a database of a quarter million differential expression effect sizes across three species, considering factors like sex and glucocorticoids.

Main Results:

  • Identified frequently reported genes affected by stress in 223 stress-control comparisons.
  • Found significant overlap in gene expression patterns between animal models and human PTSD patients.
  • Highlighted novel candidate genes (e.g., Pllp, Arrdc2, Midn) potentially involved in stress response pathways.

Conclusions:

  • This comprehensive transcriptomic resource provides a robust foundation for future research into stress-related disorders.
  • The study confirms the utility of animal models in understanding human stress physiology and PTSD.
  • Identified genes offer new targets for investigating the molecular mechanisms underlying stress responses.