Related Experiment Video
Updated: Sep 27, 2025
Sodium Taurocholate Induced Severe Acute Pancreatitis in C57BL/6 Mice
Published on: June 28, 2021
Primary hypertriglyceridemia induced pancreatitis in a cohort of Pakistani children
Sabeen Abid Khan1, Anusha Khan1, Munir Iqbal Malik1
1Paediatrics Gastroenterologist, Shifa College of Medicine, Shifa Tameer-e-Millat University, Islamabad, Pakistan.
Insights
Primary hypertriglyceridemia is a rare cause of pancreatitis in children. This study identified six pediatric cases, highlighting the importance of recognizing this condition in young patients with high triglyceride levels.
Area of Science:
- Pediatric Gastroenterology
- Endocrinology
- Metabolic Disorders
Background:
- Primary hypertriglyceridemia is uncommon in children.
- Hypertriglyceridemia-induced pancreatitis is a known complication, more frequent in adults.
- Limited data exists on pediatric cases, especially from Pakistan.
Purpose of the Study:
- To determine the frequency of hypertriglyceridemia-induced pancreatitis in children.
- To describe the clinical characteristics of pediatric patients with this condition.
- To raise awareness of primary hypertriglyceridemia as a cause of pancreatitis in pediatric populations.
Main Methods:
- Retrospective review of pediatric patients diagnosed with pancreatitis.
- Inclusion criteria: patients under 18 years with pancreatitis.
- Data collected: symptoms, signs, age, growth, lab investigations, family history of dyslipidemias or pancreatitis.
Main Results:
- Six pediatric patients with primary hypertriglyceridemia and pancreatitis were identified.
- Mean triglyceride levels were 1,599 mg/dL.
- 4 patients (66.6%) had acute pancreatitis, 1 (16.6%) recurrent, and 1 (16.6%) chronic.
Conclusions:
- This study is the first to report primary hypertriglyceridemia presenting as pancreatitis in Pakistani children.
- All identified patients had triglyceride levels exceeding 1000 mg/dL.
- Early recognition and management of hypertriglyceridemia are crucial in pediatric pancreatitis.
Objectives:
Primary hypertriglyceridemia is a rare condition in children. Hypertriglyceridemia induced pancreatitis is most commonly reported in adults, accounting for third most common cause after gallstones and alcohol consumption. The study aims to highlight the frequency of hypertriglyceridemia induced pancreatitis in a cohort of children presenting in a tertiary care hospital.
Methods:
A retrospective review of paediatric patients with pancreatitis was conducted in Shifa International hospital, Islamabad, from 2013 to 2020. All patients under 18 years of age who fulfilled the inclusion criteria were included. Medical records of patients were checked for symptoms, signs, age, growth parameters and laboratory investigations. Patients who had HTG were reviewed in detail for family history of pancreatitis or dyslipidemias.
Results:
We found a cohort of 6 patients with primary hypertriglyceridemia after excluding secondary causes. Out of these 6 patients, 4 (66.6%) were male and 2 (33.3%) were female. Minimum age of our patient was 2 months and maximum was 17 years with a mean age of 6.5 years. Two patients presented less than one year of age. Mean triglyceride levels was 1,599 + 523 mg/dL. Four patients (66.6%) had acute pancreatitis, one each (16.6%) had recurrent and chronic pancreatitis. Family history was positive for hyperlipidaemia in two patients who had positive consanguinity. Patients with positive family history were symptomatic at earlier age.
Conclusions:
This is the first study to highlight primary hypertriglyceridemia presenting as pancreatitis in paediatric population from Pakistan. All patients had triglycerides level of greater than 1000 mg/dL.
More Related Videos
07:38Preparing a Mice Model of Severe Acute Pancreatitis via a Combination of Caerulein and Lipopolysaccharide Intraperitoneal Injection
Published on: May 10, 2024
07:10Establishment of a Mouse Severe Acute Pancreatitis Model using Retrograde Injection of Sodium Taurocholate into the Biliopancreatic Duct
Published on: April 1, 2022
Related Concept Videos
01:30Acute Pancreatitis II: Clinical Manifestations and Management
01:24Chronic Pancreatitis I: Introduction
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
01:27Acute Pancreatitis I: Introduction
Acute pancreatitis is characterized by rapid inflammation of the pancreas, often caused by factors like gallstone blockage or excessive alcohol consumption. Chronic pancreatitis, on the other hand, is a slow, progressive inflammation that may result from long-term alcohol abuse, obstructions in the pancreatic duct, or genetic factors.
The causes of acute pancreatitis include:
01:29Chronic Pancreatitis II: Collaborative Care
Assessment:
01:17Gastritis-II: Pathophysiology
In acute gastritis, the gastric mucosa becomes swollen and red and undergoes superficial erosion. Superficial ulceration may lead to bleeding.
In chronic gastritis, persistent or repeated insults lead to chronic inflammatory changes and, eventually, thinning or atrophy of the gastric tissue.
Gastritis can stem from various causes, each...