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Tissue Engineering of Tumor Stromal Microenvironment with Application to Cancer Cell Invasion
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A Multidisciplinary Approach to Complex Dermal Sarcomas Ensures an Optimal Clinical Outcome
Hannah Trøstrup1,2, Amir K Bigdeli3, Christina Krogerus1
1Department of Plastic Surgery and Breast Surgery, Zealand University Hospital (SUH) Roskilde, University of Copenhagen, 4000 Roskilde, Denmark.
Cancers
|April 12, 2022
Summary
Primary dermal sarcomas (PDS) are rare, heterogeneous tumors. A multidisciplinary approach with individualized surgical planning is crucial for optimal outcomes and low recurrence rates in treating these challenging cancers.
Area of Science:
- Dermatology
- Surgical Oncology
- Pathology
Background:
- Primary dermal sarcomas (PDS) are rare, heterogeneous malignant mesenchymal tumors.
- They originate from dermal connective tissue, smooth muscle, or vessels.
- PDS can mimic benign lesions, leading to diagnostic delays.
Purpose of the Study:
- To provide a structured overview of common PDS types.
- To detail surgical recommendations and advanced reconstruction techniques.
- To discuss current adjunctive medical treatment strategies.
Main Methods:
- Review of common clinicopathological forms of PDS.
- Analysis of surgical challenges and planning.
- Evaluation of multidisciplinary treatment approaches.
Main Results:
- PDS exhibit a broad spectrum of malignant potential with some forms showing aggressive local behavior.
- Individualized surgical planning with complete margins is vital.
- Multidisciplinary collaboration across specialties is key for optimal outcomes.
Conclusions:
- Optimal aesthetic and functional outcomes with low recurrence rates are achievable through a multidisciplinary approach.
- Advanced reconstructive techniques are essential for cases with extended local invasion.
- Interdisciplinary microsurgeons should be integral to sarcoma boards.
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