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Updated: Sep 27, 2025

Engineering Artificial Factors to Specifically Manipulate Alternative Splicing in Human Cells
Published on: April 26, 2017
Alternative Splicing in Cancer and Immune Cells
Antoine Bernard1,2, Romain Boidot3,4, Frédérique Végran1,2,3
1Team CAdIR, CRI INSERM UMR1231 "Lipids, Nutrition and Cancer'', 21000 Dijon, France.
Alternative splicing (AS) generates protein diversity from limited genes and regulates cellular behavior. Dysregulated AS in cancer impacts tumor cells and the immune system, highlighting its role in immunotherapy.
Area of Science:
- Molecular Biology
- Genetics
- Immunology
Background:
- Alternative splicing (AS) dramatically expands the human proteome beyond the 20,000 protein-coding genes.
- AS is crucial for cellular regulation, particularly in immune cells, and contributes to normal cellular functions.
Purpose of the Study:
- To review the literature connecting alternative splicing and immunotherapy.
- To provide an overview of AS in immune and tumor cells, focusing on dysregulation in cancer.
Main Methods:
- Literature review focusing on alternative splicing and its role in cancer and immunity.
- Analysis of AS dysregulation events in tumor cells.
Main Results:
- Alternative splicing is implicated in nearly all hallmarks of cancer.
- Dysregulated AS in tumors affects the tumor-immune system interplay.
Conclusions:
- Alternative splicing is a key factor in cancer development and progression.
- Understanding AS in cancer is critical for advancing immunotherapy strategies.
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