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Oogenesis

Oogenesis

In human women, oogenesis produces one mature egg cell or ovum for every precursor cell that enters meiosis. This process differs in two unique ways from the equivalent procedure of spermatogenesis in males. First, meiotic divisions during oogenesis are asymmetric, meaning that a large oocyte (containing most of the cytoplasm) and minor polar body are produced as a result of meiosis I, and again following meiosis II. Since only oocytes will go on to form embryos if fertilized, this unequal...

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Related Experiment Video

Updated: Sep 27, 2025

Proteolytically Degraded Alginate Hydrogels and Hydrophobic Microbioreactors for Porcine Oocyte Encapsulation

Proteolytically Degraded Alginate Hydrogels and Hydrophobic Microbioreactors for Porcine Oocyte Encapsulation

Published on: July 30, 2020

Artificial Oocyte: Development and Potential Application.

Reza K Oqani¹, Seongjun So¹, Yeonmi Lee^1,2

¹Department of Biomedical Science, College of Life Science, CHA University, Seongnam 13488, Korea.

|April 12, 2022

Summary

This summary is machine-generated.

Creating artificial oocytes from stem cells offers new hope for infertility. This research explores in vitro oogenesis for advanced reproductive technologies and human fertility applications.

Keywords:

artificial oocyte assisted reproductive technologies haploidization of somatic chromosomes oogenesis stem cells

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Last Updated: Sep 27, 2025

Proteolytically Degraded Alginate Hydrogels and Hydrophobic Microbioreactors for Porcine Oocyte Encapsulation

Proteolytically Degraded Alginate Hydrogels and Hydrophobic Microbioreactors for Porcine Oocyte Encapsulation

Published on: July 30, 2020

In Vitro Culture Strategy for Oocytes from Early Antral Follicle in Cattle

In Vitro Culture Strategy for Oocytes from Early Antral Follicle in Cattle

Published on: July 8, 2020

Human Egg Maturity Assessment and Its Clinical Application

Human Egg Maturity Assessment and Its Clinical Application

Published on: August 19, 2019

Area of Science:

Reproductive Biology
Stem Cell Science
Developmental Biology

Background:

Millions face infertility, with rising numbers of infertile couples and individuals annually.
Current assisted reproductive technologies (ART) are ineffective for patients lacking functional germ cells.
Developing alternative methods like artificial oocyte generation is crucial.

Purpose of the Study:

To review the principles of oocyte development and oogenesis.
To examine in vitro generation of functional oocytes from various stem cell sources.
To discuss next-generation ART and reproductive applications of in vitro oogenesis.

Main Methods:

Review of landmark studies on in vivo oogenesis mechanisms.
Analysis of in vitro oocyte generation from mouse and human stem cells (including germline stem cells (GSCs) and pluripotent stem cells (PSCs)).
Exploration of artificial oocyte applications in ART.

Main Results:

Oocytes can be generated in vitro from diverse sources like fetal gonads and stem cells.
Understanding in vivo oogenesis informs in vitro generation strategies.
Artificial oocytes present potential for next-generation ART.

Conclusions:

In vitro oogenesis from stem cells provides a promising alternative for infertility.
This technology holds significant potential for both basic research and medical applications in human fertility.
Artificial oocytes could revolutionize assisted reproductive technologies.