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Updated: Sep 27, 2025

Single-Cell Calcium Imaging for Studying the Activation of Calcium Ion Channels
Published on: December 13, 2024
On the Connections between TRPM Channels and SOCE.
Guilherme H Souza Bomfim1, Barbara A Niemeyer2, Rodrigo S Lacruz1
1Department of Molecular Pathobiology, New York University College of Dentistry, New York, NY 10010, USA.
Transient Receptor Potential Melastatin (TRPM) channels and store-operated calcium entry (SOCE) are crucial for cellular calcium regulation. This review explores their interconnected roles in calcium handling and highlights emerging evidence of their interaction.
Area of Science:
- Cellular Biology
- Ion Channel Physiology
- Molecular Mechanisms
Background:
- Plasma membrane protein channels regulate ion passage into cells.
- Calcium ion homeostasis is maintained by channels, ATPases, and exchangers.
- CRAC and TRPM channels exhibit varying Ca2+ selectivity.
Purpose of the Study:
- To review the function of TRPM channels and SOCE in calcium handling.
- To highlight the evidence for the interaction between TRPM and SOCE pathways.
- To discuss the emerging molecular details of this interrelationship.
Main Methods:
- Literature review of studies on TRPM channels and SOCE.
- Analysis of research on calcium ion transport mechanisms.
- Synthesis of current understanding of TRPM-SOCE interactions.
Main Results:
- TRPM channels (TRPM1-8) are permeable to various cations including Ca2+ and Mg2+.
- SOCE involves the coupling of ORAI channels with STIM proteins.
- Evidence suggests a functional link between TRPM channels and SOCE.
Conclusions:
- TRPM channels and SOCE play significant roles in cellular calcium regulation.
- The interaction between TRPM and SOCE is an active area of research.
- Further investigation is needed to elucidate the molecular basis of TRPM-SOCE interplay.
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