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Aspartic Acid Stabilized Iron Oxide Nanoparticles for Biomedical Applications
Mihaela Răcuciu1, Lucian Barbu-Tudoran2,3, Simona Oancea4
1Environmental Sciences and Physics Department, Faculty of Sciences, "Lucian Blaga" University of Sibiu, Dr. I. Ratiu Str., no. 5-7, 550012 Sibiu, Romania.
Nanomaterials (Basel, Switzerland)
|April 12, 2022
Summary
Aspartic acid stabilized iron oxide nanoparticles (A-IONPs) were synthesized with controlled size and shape. These A-IONPs show promise for biomedical applications due to their favorable characteristics.
Area of Science:
- Materials Science
- Nanotechnology
- Biomedical Engineering
Background:
- Iron oxide nanoparticles (IONPs) are widely explored for biomedical uses.
- Stabilization is crucial for controlling nanoparticle properties and ensuring biocompatibility.
- Aspartic acid offers potential as a stabilizing agent due to its chemical properties.
Purpose of the Study:
- To synthesize and characterize aspartic acid stabilized iron oxide nanoparticles (A-IONPs).
- To investigate the structural, magnetic, and physical properties of A-IONPs.
- To evaluate the suitability of A-IONPs for biomedical applications.
Main Methods:
- Co-precipitation method in an aqueous medium for A-IONP synthesis.
- Characterization using Transmission Electron Microscopy (TEM), X-ray Diffraction (XRD), Fourier-Transform Infrared Spectroscopy (ATR-FTIR), Energy-Dispersive X-ray Spectroscopy (EDS), Differential Scanning Calorimetry (DSC), Thermogravimetric Analysis (TG), Dynamic Light Scattering (DLS), Nanoparticle Tracking Analysis (NTA), and Vibrating Sample Magnetometry (VSM).
- Quantum-mechanical and theoretical studies (Hartree-Fock, density functional algorithms) to understand aspartic acid-nanoparticle interactions.
Main Results:
- Globular A-IONPs with narrow size distribution were successfully prepared.
- TEM, XRD, and VSM data indicated particle diameters around 9 nm.
- Zeta-potential of -11.7 mV and hydrodynamic diameter of 153.9 nm were measured, suggesting colloidal stability.
- Theoretical studies supported the interaction of aspartic acid with nanoparticles and water molecules.
Conclusions:
- Aspartic acid effectively stabilizes iron oxide nanoparticles.
- The synthesized A-IONPs exhibit desirable physical and magnetic properties.
- The characterized A-IONP suspension is recommended for further investigation in biomedical applications.
