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Updated: Sep 27, 2025

Native Cell Membrane Nanoparticles System for Membrane Protein-Protein Interaction Analysis
Published on: July 16, 2020
Engineered Nanoparticle-Protein Interactions Influence Protein Structural Integrity and Biological Significance
Surabhi Jaiswal1,2, Amit Manhas1, Alok Kumar Pandey3
1Biomolecular Toxicology Lab, Food, Drug and Chemical Toxicology Division, CSIR-Indian Institute of Toxicology Research, Lucknow 226001, India.
Abstract:
Engineered nanoparticles (ENPs) are artificially synthesized particles with unique physicochemical properties. ENPs are being extensively used in several consumer items, elevating the probability of ENP exposure to biological systems. ENPs interact with various biomolecules like lipids, proteins, nucleic acids, where proteins are most susceptible. The ENP-protein interactions are mostly studied for corona formation and its effect on the bio-reactivity of ENPs, however, an in-depth understanding of subsequent interactive effects on proteins, such as alterations in their structure, conformation, free energy, and folding is still required. The present review focuses on ENP-protein interactions and the subsequent effects on protein structure and function followed by the therapeutic potential of ENPs for protein misfolding diseases.
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