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A Multimarker Model for Aberrant Cardiac Geometry after Preeclampsia
Zenab Mohseni-Alsalhi1, Sophie A J S Laven1, Emma B N J Janssen1
1Department of Obstetrics and Gynecology, School for Oncology and Developmental Biology, GROW, Maastricht University Medical Center (MUMC+), MD 6200 Maastricht, The Netherlands.
Journal of Clinical Medicine
|April 12, 2022
Summary
Preeclampsia survivors often develop abnormal heart changes, increasing heart failure risk. This study identifies key markers like blood pressure and plasma volume to predict cardiac remodeling, aiding early screening post-delivery.
Area of Science:
- Cardiovascular Medicine
- Reproductive Health
- Biomarker Research
Background:
- Preeclampsia significantly increases long-term cardiovascular disease risk, including subclinical heart failure.
- Abnormal cardiac remodeling is observed in up to 25% of women with a history of preeclampsia within ten years postpartum.
- Early identification of at-risk individuals is crucial for preventing symptomatic heart failure.
Purpose of the Study:
- To develop a predictive model for aberrant cardiac geometry in women with a history of preeclampsia.
- To identify key clinical and biochemical markers associated with cardiac remodeling post-delivery.
- To establish a screening tool for early detection of subclinical heart changes.
Main Methods:
- Cross-sectional study including 752 women with preeclampsia history.
- Cardiovascular evaluation 6 months to 5 years postpartum: cardiac ultrasound, blood pressure, plasma volume, and biomarkers (CRP, uric acid, fibrinogen).
- Development of a multimarker linear regression model to identify predictors of cardiac remodeling (relative wall thickness and left ventricular mass index).
Main Results:
- Systolic blood pressure (SBP) and plasma volume (PV) independently correlated with relative wall thickness (RWT) and left ventricular mass index (LVMi).
- C-reactive protein (CRP) and uric acid showed independent correlation with RWT.
- Fibrinogen did not demonstrate a significant relationship with LVMi or RWT.
Conclusions:
- Specific mechanical (SBP, PV) and biochemical (CRP, uric acid) factors are associated with abnormal cardiac remodeling in former preeclamptic women.
- These identified markers can contribute to a screening model for aberrant cardiac geometry before clinical heart failure symptoms manifest.
- Further research into these factors may lead to targeted interventions for cardiovascular risk reduction in this population.
