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Correction: Mukavi et al. Antiprotozoal Aminosteroid Alkaloids from <i>Buxus obtusifolia</i> (Mildbr.) Hutch. <i>Molecules</i> 2025, <i>30</i>, 4558.

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Natural Products with Antitumor Potential Targeting the MYB-C/EBPβ-p300 Transcription Module.

Thomas J Schmidt1, Karl-Heinz Klempnauer2

  • 1Institute of Pharmaceutical Biology and Phytochemistry (IPBP), University of Münster, PharmaCampus-Corrensstraße 48, D-48149 Munster, Germany.

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PubMed
Summary

Natural products inhibit the MYB-C/EBPβ-p300 transcription module, offering potential anti-leukemia drugs. These compounds, including sesquiterpene lactones and naphthoquinones, target key gene expression in acute myeloid leukemia and T-cell acute lymphoblastic leukemia.

Keywords:
C/EBPβMYBcancercelastrolleukemianaphthoquinonenatural productp300plumbaginsesquiterpene lactonetranscription factorwithaferin Awithanolide

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Area of Science:

  • Molecular Biology
  • Cancer Research
  • Natural Products Chemistry

Background:

  • The transcription factor MYB is crucial for hematopoietic progenitor cell development.
  • MYB collaborates with C/EBP transcription factors and co-activators like p300/CBP in myeloid gene expression.
  • MYB plays a role in acute T-cell leukemia (T-ALL) and acute myeloid leukemia (AML).

Purpose of the Study:

  • To review natural product inhibitors of the MYB-C/EBPβ-p300 transcriptional module.
  • To explore their potential as anti-leukemia therapeutics.
  • To summarize structure-activity relationships and future development potential.

Main Methods:

  • Literature review of natural products targeting the MYB-C/EBPβ-p300 module.
  • Analysis of various structural classes of inhibitors (sesquiterpene lactones, steroid lactones, quinone methide triterpenes, naphthoquinones).
  • Examination of inhibitory mechanisms and structure-activity relationships.

Main Results:

  • Identification of diverse natural product classes that interfere with MYB-C/EBPβ-p300 activity.
  • Demonstration of different inhibitory mechanisms employed by these compounds.
  • Established structure-activity relationships guiding inhibitor development.

Conclusions:

  • Natural products offer a promising avenue for developing novel anti-leukemia drugs by targeting the MYB-C/EBPβ-p300 module.
  • Further research into these compounds could lead to new therapeutic strategies for AML and T-ALL.
  • Understanding structure-activity relationships is key for optimizing drug development.