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Updated: Sep 27, 2025

Functionalized Spirocyclic Heterocycle Synthesis and Cytotoxicity Assay
Published on: February 9, 2021
Insights on the Synthesis of N-Heterocycles Containing Macrocycles and Their Complexion and Biological Properties
Fouad Malek1, Tarik Harit1, Mounir Cherfi1
1Laboratory of Applied Chemistry and Environment-ECOMP, Faculty of Sciences, Mohammed First University, Bd Mohamed VI, Oujda 60000, Morocco.
Abstract:
Macrocyclic chemistry has been extensively developed over the past several decades. In fact, the architecture of new macrocyclic models has undergone exponential growth to offer molecules with specific properties. In this context, an attempt is made in this study to provide an overview of some synthetic methods allowing the elaboration of N-heterocycles containing macrocycles (imidazole, triazole, tetrazole, and pyrazole), as well as their applications in the complexation of metal cations or as pharmacological agents.
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