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Propolis Integration Methods into Solutions for Highly Loaded Propolis Fibers by Needleless Electrospinning
Zane Zelca1, Silvija Kukle1, Sarmite Janceva2
1Institute of Design Technology, Faculty of Materials Science and Applied Chemistry, Riga Technical University, Kipsala Street 6, LV-1084 Riga, Latvia.
Molecules (Basel, Switzerland)
|April 12, 2022
Summary
Researchers developed a novel method to create stable propolis/PVA fibers using electrospinning. These biocompatible micro- and nanofibers incorporate over 73% propolis, offering promising biomedical and bioprotective applications.
Area of Science:
- Materials Science
- Biotechnology
- Natural Products Chemistry
Background:
- Propolis, a bee-derived resin, possesses significant antibacterial, antiviral, anti-inflammatory, antifungal, and antioxidant properties.
- Traditional propolis processing faces challenges due to its limited solubility.
- Developing stable matrices for biologically active compounds is crucial for targeted delivery.
Purpose of the Study:
- To create stable propolis/polyvinyl alcohol (PVA) solutions for fiber production via electrospinning.
- To maximize propolis content within the fibers while preserving its bioactivity.
- To explore the biomedical and bioprotective potential of the resulting propolis-based fibers.
Main Methods:
- Utilized various propolis extracts to enhance propolis loading in fibers.
- Optimized polyvinyl alcohol (PVA) molecular weight for efficient electrospinning and desired fiber characteristics.
- Characterized electrospinning solutions (viscosity, pH, conductivity, density, shelf life) before and after propolis addition.
- Employed a cylindrical electrode for stable, industrial-scale electrospinning of propolis/PVA solutions.
- Assessed total flavonoid content in propolis extracts to predict bioactivity.
Main Results:
- Successfully produced homogeneous micro- and nano-fiber webs with high propolis content (over 73 wt%).
- Achieved stable electrospinning processes for all tested propolis/PVA combinations.
- Demonstrated that the developed method overcomes propolis solubility limitations.
- Obtained fibers without toxic agents, using edible and human-safe materials.
Conclusions:
- The electrospinning of propolis/PVA offers a viable strategy for creating advanced biomaterials.
- The produced fibers exhibit significant potential for biomedical and bioprotective applications.
- This method enables high incorporation of propolis into a stable, fibrous matrix, preserving its natural bioactivity.
