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Updated: Sep 27, 2025
Author Spotlight: Innovative Microneedle-Based Strategies for Enhanced Exosome Delivery and Stability
Published on: July 12, 2024
Levonorgestrel Microneedle Array Patch for Sustained Release Contraception: Formulation, Optimization and In Vivo
Amarjitsing Rajput1,2, Riyaz Ali M Osmani1,3, Achyut Khire1
1Nanomedicine Lab, Department of Biosciences and Bioengineering (BSBE), Indian Institute of Technology Bombay (IITB), Mumbai 400076, India.
Background:
The goal of this work was to develop a levonorgestrel liposome-loaded microneedle array patch for contraception.
Methods:
Levonorgestrel-loaded liposome was formulated by a solvent injection technique, characterized, and studied.
Results:
The formulated liposomes were characterized for particle size (147 ± 8 nm), polydispersity index (0.207 ± 0.03), zeta potential (-23 ± 4.25 mV), drug loading (18 ± 3.22%) and entrapment efficiency (85 ± 4.34%). A cryo high-resolution transmission electron microscopy and cryo field emission gun scanning electron microscopy study showed spherical shaped particles with a smooth surface. The in vitro drug release and in vivo pharmacokinetic study showed sustained behaviour of Levonorgestrel for 28 days.
Conclusion:
The levonorgestrel liposome-loaded microneedle array patch showed better contraception than the drug-loaded microneedle array patch.
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