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Extracellular HSPs: The Potential Target for Human Disease Therapy
Dong-Yi Li1, Shan Liang1, Jun-Hao Wen1
1Key Laboratory of Prevention and Management of Chronic Kidney Disease of Zhanjiang, Institute of Nephrology, Affiliated Hospital of Guangdong Medical University, Zhanjiang 524001, China.
Molecules (Basel, Switzerland)
|April 12, 2022
Summary
Heat shock proteins (HSPs), typically intracellular, are increasingly found extracellularly (eHSPs). These eHSPs significantly influence inflammation and immunity, offering potential therapeutic targets for diseases like cancer.
Area of Science:
- Molecular Biology
- Immunology
- Cell Biology
Background:
- Heat shock proteins (HSPs) are conserved molecular chaperones primarily functioning intracellularly.
- Emerging evidence indicates HSPs are released extracellularly, termed extracellular HSPs (eHSPs).
- eHSPs play critical roles in modulating inflammation and immune responses.
Purpose of the Study:
- To review the types and secretion mechanisms of eHSPs.
- To highlight the functions of eHSPs in inflammation and immunity.
- To explore targeting eHSPs for therapeutic strategies, using cancer as a model.
Main Methods:
- Literature review of studies on HSPs, eHSPs, inflammation, and immunity.
- Analysis of mechanisms for eHSP secretion.
- Case study on cancer and eHSP therapeutic potential.
Main Results:
- HSPs can be secreted and function in the extracellular space.
- eHSPs are implicated in various human diseases linked to inflammation and immunity.
- eHSPs exhibit diverse roles in immune modulation.
Conclusions:
- Extracellular HSPs are key mediators of inflammation and immunity.
- Understanding eHSP functions is crucial for developing novel therapies.
- Targeting eHSPs presents a promising avenue for treating inflammatory and immune-related diseases.
