Related Experiment Video

Updated: Sep 27, 2025

SUMO-Binding Entities SUBEs as Tools for the Enrichment, Isolation, Identification, and Characterization of the SUMO Proteome in Liver Cancer
08:29

SUMO-Binding Entities SUBEs as Tools for the Enrichment, Isolation, Identification, and Characterization of the SUMO Proteome in Liver Cancer

Published on: November 1, 2019

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The Next Frontier: Translational Development of Ubiquitination, SUMOylation, and NEDDylation in Cancer

Nicole E Pellegrino1, Arcan Guven1, Kayleigh Gray1

  • 1BERG, 500 Old Connecticut Path, Framingham, MA 01701, USA.

International Journal of Molecular Sciences
|April 12, 2022
PubMed

Insights

Post-translational modifications like ubiquitination, SUMOylation, and NEDDylation regulate cellular processes. Aberrations in these pathways are linked to cancer, highlighting their therapeutic potential.

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Cell Biology

Background:

  • Post-translational modifications (PTMs) are crucial for cellular functions, including proteostasis and stress adaptation.
  • Dysregulated PTMs are implicated in diseases like cancer and neurodegenerative disorders.
  • Ubiquitin and ubiquitin-like modifiers (SUMOylation, NEDDylation) share structural and enzymatic similarities.

Purpose of the Study:

  • To review regulatory mechanisms and assay capabilities of ubiquitination, SUMOylation, and NEDDylation.
  • To highlight the interplay between these PTMs in cancer biology.
  • To explore their roles in tumorigenesis.

Main Methods:

  • Literature review of regulatory mechanisms.
  • Analysis of assay capabilities for PTMs.
  • Synthesis of current understanding of PTMs in cancer.

Main Results:

  • Ubiquitination, SUMOylation, and NEDDylation pathways share conserved features.
  • Aberrations in these pathways contribute to tumorigenesis.
  • These PTMs influence tumor metabolism, immune microenvironment, and cancer stemness.

Conclusions:

  • Understanding the interplay of ubiquitination, SUMOylation, and NEDDylation is vital for cancer research.
  • These PTMs represent potential targets for cancer therapy.
  • Further research into PTM regulatory mechanisms and assays is warranted.
Keywords:
NEDDylationSUMOylationcancerpost-translational modificationsubiquitination

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