Related Experiment Video

Updated: Sep 27, 2025

Real-Time Quantitative Measurement of Tumor Cell Migration and Invasion Following Synthetic mRNA Transfection
11:00

Real-Time Quantitative Measurement of Tumor Cell Migration and Invasion Following Synthetic mRNA Transfection

Published on: June 23, 2023

1.3K

ELK3 Controls Gastric Cancer Cell Migration and Invasion by Regulating ECM Remodeling-Related Genes

Minwook Lee1, Hyeon-Ju Cho1, Kyung-Soon Park1

  • 1Department of Biomedical Science, College of Life Science, CHA University, Pangyo-Ro 335, Bundang-gu, Seongnam-si 463-400, Korea.

International Journal of Molecular Sciences
|April 12, 2022
PubMed

Insights

The E26 transformation-specific (ETS) transcription factor ELK3 is crucial for gastric cancer cell migration and invasion. ELK3 regulates extracellular matrix remodeling genes, impacting cancer cell dissemination and patient prognosis.

Area of Science:

  • Molecular Biology
  • Oncology
  • Genetics

Background:

  • Metastatic gastric cancer has a poor prognosis despite current treatments.
  • The molecular mechanisms driving gastric cancer cell dissemination remain largely unknown.

Purpose of the Study:

  • To investigate the role of the ELK3 gene in gastric cancer cell migration and invasion.
  • To identify the molecular pathways regulated by ELK3 in cancer cell dissemination.

Main Methods:

  • In silico analyses to assess gene expression correlations.
  • Examination of ELK3's role in modulating extracellular matrix (ECM) remodeling genes.

Main Results:

  • ELK3 is essential for gastric cancer cell migration and invasion.
  • ELK3 regulates ECM remodeling genes including BMP1, LOXL2, SNAI1, SERPINF1, DCN, and NID1.
  • High ELK3 expression correlates with upregulated ECM genes and poorer patient prognosis.

Conclusions:

  • ELK3 is a key regulator of gastric cancer cell dissemination.
  • ELK3 facilitates cancer cell spread by remodeling the extracellular matrix.
  • ELK3 and associated ECM genes represent potential therapeutic targets for metastatic gastric cancer.
Keywords:
ETS transcription factor ELK3cell invasioncell migrationextracellular matrix remodelinggastric cancer metastasis

More Related Videos

An Immunofluorescent Method for Characterization of Barrett’s Esophagus Cells08:54

An Immunofluorescent Method for Characterization of Barrett’s Esophagus Cells

Published on: July 20, 2014

14.1K
Impedance-based Real-time Measurement of Cancer Cell Migration and Invasion09:23

Impedance-based Real-time Measurement of Cancer Cell Migration and Invasion

Published on: April 2, 2020

6.6K

Related Concept Videos

Role of Ephrin-Eph Signalling in Intestinal Stem Cell Renewal01:22

Role of Ephrin-Eph Signalling in Intestinal Stem Cell Renewal

Erythropoietin-producing hepatocellular carcinoma receptor (Eph) and its ligand, Eph receptor-interacting protein (Ephrin) were first discovered in the human carcinoma cell line, hence the name. Ephrin-Eph interaction guides cells to reach their appropriate location in adult tissues. They also play an essential role in the immune system by helping in immune cell migration, adhesion, and activation. Based on their structure and function, Eph is divided into two classes — EphA and EphB.
2.3K
Mitogens and the Cell Cycle02:38

Mitogens and the Cell Cycle

Mitogens and their receptors play a crucial role in controlling the progression of the cell cycle. However, the loss of mitogenic control over cell division leads to tumor formation. Therefore, mitogens and mitogen receptors play an important role in cancer research. For instance, the epidermal growth factor (EGF) - a type of mitogen and its transmembrane receptor (EGFR), decides the fate of the cell's proliferation. When EGF binds to EGFR, a member of the ErbB family of tyrosine kinase...
7.0K
Cancer Cell Migration through Invadopodia01:35

Cancer Cell Migration through Invadopodia

Invadosome is a broad category of cell surface structures with proteolytic activity that  degrades the extracellular matrix (ECM). Invadosomes are present in normal cell types, including macrophages, endothelial cells, and neurons, as well as tumor cells. Although the macrophage podosomes and tumor cell invadopodia are classified as invadosomes, they have different structures, molecular pathways, and functions. Podosomes are short structures that last for a few minutes. However,...
2.4K
Role Of Notch Signalling In Intestinal Stem Cell Renewal01:12

Role Of Notch Signalling In Intestinal Stem Cell Renewal

Notch signaling was first discovered in Drosophila melanogaster, where it is involved in cell lineage differentiation. Notch signaling regulates the maintenance and differentiation of intestinal stem cells or ISCs by controlling the expression of atonal homolog 1 or Atoh1. Atoh1 directs cells to differentiate into secretory cells.
Direct cell-to-cell contact is needed for the activation of Notch signaling. The signal is initiated when a notch ligand binds to a receptor on an adjacent cell, also...
2.2K
The Tumor Microenvironment02:17

The Tumor Microenvironment

Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
6.8K