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Central and Peripheral NPY Age-Related Regulation: A Comparative Analysis in Fish Translational Models.

Daniela Giaquinto1, Elena De Felice2, Chiara Attanasio1

  • 1Department Veterinary Medicine and Animal Production, University of Naples Federico II, Via F. Delpino 1, 80137 Naples, Italy.

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|April 12, 2022
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Summary
This summary is machine-generated.

Neuropeptide Y (NPY) brain levels rise with age in fish, while gut levels decline, offering insights into aging mechanisms. This study compares NPY regulation in short- and long-lived fish species.

Keywords:
African turquoise killifishagingbraingutneuropeptideszebrafish

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Area of Science:

  • Neuroscience
  • Aging Research
  • Comparative Biology

Background:

  • Neuropeptide Y (NPY) is crucial for regulating food intake and neuronal survival, with roles in aging.
  • The NPY system's age-related changes are not fully understood across different vertebrate species.
  • Nothobranchius furzeri (short-lived) and Danio rerio (long-lived) offer distinct models for studying aging.

Purpose of the Study:

  • To investigate the age-related regulation of NPY in the brain and foregut of N. furzeri and D. rerio.
  • To compare NPY system function in species with contrasting lifespans.
  • To elucidate mechanisms of neuropeptide synthesis and function during aging.

Main Methods:

  • Comparative analysis of NPY expression and localization in brain and foregut tissues.
  • Age-dependent assessment of NPY levels in young and old fish.
  • Focus on the Npya form of NPY, as identified in the studied teleost species.

Main Results:

  • NPY is centrally regulated in both fish species.
  • Brain NPY levels increase with age in both N. furzeri and D. rerio.
  • Gut NPY levels decrease significantly in aged animals, showing localization in enteroendocrine cells and myenteric plexus.

Conclusions:

  • Age-related NPY changes in the gut mirror those in other vertebrates.
  • Elevated brain NPY in aging fish presents opportunities for studying its role in neuronal survival and aging.
  • These findings support the use of these fish models for future experimental and translatable approaches in aging research.