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Updated: Sep 27, 2025
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3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache
Published on: June 2, 2014
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Association between Gastrointestinal Diseases and Migraine
Jemin Kim1, Sujin Lee1, Kiyon Rhew1
1College of Pharmacy, Dongduk Women's University, 60 Hwarangro-13gil, Seongbuk-gu, Seoul 02748, Korea.
Summary
Migraine is significantly more common in individuals with gastrointestinal (GI) diseases. The risk of migraine increases with the number of co-occurring GI conditions, highlighting the gut-brain axis connection.
Area of Science:
- Neurology
- Gastroenterology
- Public Health
Background:
- Migraine is a prevalent neurological disorder.
- Emerging evidence suggests a link between gastrointestinal (GI) diseases and increased migraine incidence.
- The gut-brain axis describes the bidirectional communication between the GI tract and the central nervous system.
Purpose of the Study:
- To investigate the association between common GI diseases and migraine.
- To determine if the prevalence of migraine is higher in patients with diagnosed GI conditions.
Main Methods:
- Utilized the HIRA dataset, including 781,115 patients.
- Analyzed data for patients diagnosed with migraine and specific GI diseases (peptic ulcer disease, dyspepsia, inflammatory bowel disease, irritable bowel syndrome, gastroesophageal disease).
- Adjusted for age, gender, and insurance type in the analysis.
Main Results:
- Migraine prevalence was 3.5 times higher in patients with one or more GI diseases (ORadj = 3.46).
- Migraine prevalence increased with a higher number of comorbid GI diseases.
- GI disease prevalence was also higher in patients using both preventive and acute migraine medications.
Conclusions:
- A significant association exists between GI diseases and migraine.
- The number of co-occurring GI diseases correlates with increased migraine prevalence.
- Findings support the role of the gut-brain axis in migraine pathophysiology.
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