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Technical Aspect of the Automated Synthesis and Real-Time Kinetic Evaluation of [11C]SNAP-7941
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Advances in Sulfonamide Kappa Opioid Receptor Antagonists: Structural Refinement and Evaluation of CNS Clearance

Huiyong Ma1,2, Tarsis Brust3, Kevin J Frankowski1,2

  • 1Center for Integrative Chemical Biology and Drug Discovery, UNC Eshelman School of Pharmacy, 125 Mason Farm Road, CB 7363, Chapel Hill, North Carolina 27599, United States.

ACS Chemical Neuroscience
|April 12, 2022
PubMed

Keywords:
conformational constraintin vivo pharmacokineticsopioid receptorssteric effectsstructure−activity relationshiptetrahydroisoquinolines

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