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Emerging role of competing endogenous RNA and associated noncoding RNAs in thyroid cancer

Qian Bai1,2, Zhenjie Pan1, Ghulam Nabi3

  • 1Department of Anesthesiology, The Second Affiliated Hospital of Zhengzhou University Zhengzhou 450000, Henan, China.

American Journal of Cancer Research
|April 12, 2022
PubMed

Insights

Regulatory interactions among non-coding RNAs (ncRNAs) are crucial in thyroid cancer. Competing endogenous RNA (ceRNA) networks, involving long non-coding RNAs (lnRNAs), pseudogenes, and microRNAs (miRNAs), are implicated in thyroid cancer progression and drug resistance.

Area of Science:

  • Endocrinology
  • Molecular Biology
  • Oncology

Background:

  • Thyroid cancer is the most common endocrine malignancy, with limited treatment options for certain types.
  • Understanding thyroid cancer's multistep carcinogenesis is vital for developing effective treatment strategies.
  • Non-coding RNAs (ncRNAs) are increasingly linked to thyroid cancer progression, but their regulatory interactions are not fully understood.

Purpose of the Study:

  • To review the emerging roles of competing endogenous RNA (ceRNA) members in thyroid cancer.
  • To summarize current knowledge on ceRNA networks, including long non-coding RNAs (lnRNAs), pseudogenes, and microRNAs (miRNAs), in thyroid cancer.

Main Methods:

  • Literature review of studies investigating ncRNAs and ceRNA networks in thyroid cancer.
  • Analysis of regulatory interactions among pseudogenes, lnRNAs, circular RNAs (circRNAs), and miRNAs.
  • Examination of ceRNA deregulation in thyroid cancer development, invasion, metastasis, epithelial-mesenchymal transition (EMT), and drug resistance.

Main Results:

  • ceRNA networks are deregulated in thyroid cancer development, invasion, and metastasis.
  • ceRNA deregulation is associated with epithelial-mesenchymal transition (EMT) and drug resistance in thyroid cancer.
  • Numerous ceRNA networks play significant roles in various aspects of thyroid cancer progression.

Conclusions:

  • Understanding ceRNA network deregulation is crucial for developing early diagnostic markers and effective therapeutic strategies for thyroid cancer.
  • Further research into novel ceRNA members and their interactions can advance thyroid cancer treatment.
  • ceRNA mechanisms offer promising avenues for improving thyroid cancer management and patient outcomes.
Keywords:
RNA biologyceRNAcirc RNAlnc RNAmiRNAthyroid cancer

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