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Related Experiment Video

Updated: Sep 27, 2025

Scleral Cross-linking Using Riboflavin and Ultraviolet-A Radiation for Prevention of Axial Myopia in a Rabbit Model
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Lupus-Induced Myopic Shift.

Sara Safari1, Thomas A Weppelmann1

  • 1Department of Ophthalmology, University of South Florida (USF) Health Morsani College of Medicine, Tampa, USA.

Cureus
|April 12, 2022
PubMed
Summary
This summary is machine-generated.

Systemic lupus erythematosus (SLE) can rarely cause an acute myopic shift, a rapid worsening of nearsightedness. This case highlights a young woman’s sudden vision loss due to lupus, emphasizing the need for comprehensive diagnosis.

Keywords:
lupus nephritismyopic shiftnephritisperiorbital edemasystemic lupus erythematosus

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Area of Science:

  • Ophthalmology
  • Rheumatology
  • Internal Medicine

Background:

  • Ophthalmic manifestations are common in systemic lupus erythematosus (SLE).
  • Acute myopic shift, a rapid worsening of myopia, is a rare SLE presentation.
  • Early diagnosis and management are crucial for SLE patients.

Observation:

  • A young woman presented with blurry vision and bleeding gums.
  • Her myopia progressed significantly from -4.0D to -7.0D (RE) and -8.2D (LE).
  • Previous lymph node biopsy was inconclusive for lymphoma or leukemia.

Findings:

  • Blood tests revealed pancytopenia, kidney damage, and elevated inflammatory markers.
  • These findings were indicative of active systemic lupus erythematosus (SLE).
  • A diagnosis of acute binocular myopic shift secondary to SLE was established.

Implications:

  • This case underscores the importance of considering SLE in patients with unexplained acute myopic shifts.
  • Ophthalmologists and rheumatologists should collaborate for timely diagnosis and treatment.
  • Prompt SLE management may prevent further ocular and systemic complications.