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Related Experiment Video

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Neonatal Murine Cochlear Explant Technique as an In Vitro Screening Tool in Hearing Research

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Published on: June 8, 2017

Recent advancements in cell-based models for auditory disorders.

Jake Langlie¹, Ariel Finberg¹, Nathalie B Bencie¹

¹Department of Otolaryngology, Cochlear Implant and Hearing Research Laboratory, University of Miami Miller School of Medicine, Miami, Florida, USA.

Bioimpacts : BI

|April 12, 2022

Summary

Advancements in cell-based models are moving towards 3D structures and organoids for auditory disorders. These models better mimic inner ear conditions, aiding in the development of targeted therapeutics.

Keywords:

3D model Auditory system Cell-based models Organoid model Spiral ganglion neurons Stem cell

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Area of Science:

Otolaryngology
Regenerative Medicine
Cell Biology

Background:

Cell-based models are crucial for studying auditory disorders.
Current models often neglect supporting cells crucial for hair cell function.
A shift towards more physiologically relevant models is needed.

Purpose of the Study:

To review the evolution of cell-based models for auditory disorders.
To highlight the progression from 2D to 3D models and organoids.
To discuss the potential of these advanced models in disease research.

Main Methods:

Review of recent literature on cell-based auditory disorder models.
Focus on the transition to three-dimensional (3D) and organoid systems.
Analysis of molecular targets and transcription factors for inner ear cell generation.

Main Results:

Research is progressing from 2D to 3D cell-based models for auditory disorders.
Three-dimensional (3D) models and organoids are emerging as advanced tools.
These models increasingly mimic in vivo pathophysiology.

Conclusions:

3D inner ear models and organoids are novel and evolving.
They bridge the gap between cell culture and in vivo studies.
3D models offer significant potential for understanding auditory disorders and developing therapeutics.