Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Classification of beta-lactamases.

A Bauernfeind

    Reviews of Infectious Diseases
    |November 1, 1986
    PubMed
    Summary
    This summary is machine-generated.

    Beta-lactamase classification is evolving beyond substrate activity. New methods like biophysical characterization and sequence analysis are improving the categorization of these crucial enzymes.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    An evaluation of the activity of cephalosporins against Pseudomonas aeruginosa.

    The Journal of antimicrobial chemotherapy·2009
    Same author

    Patient retention and attrition on antiretroviral treatment at district level in rural Malawi.

    Transactions of the Royal Society of Tropical Medicine and Hygiene·2009
    Same author

    Extended-spectrum beta-lactamase-producing Serratia marcescens outbreak in a Bulgarian hospital.

    The Journal of hospital infection·2008
    Same author

    Nosocomial bloodstream infections with Burkholderia stabilis.

    The Journal of hospital infection·2004
    Same author

    Extended-spectrum beta-lactamase (ESBL) CTX-M-15-producing Escherichia coli and Klebsiella pneumoniae in Sofia, Bulgaria.

    Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases·2004
    Same author

    Sequential genotyping of Pseudomonas aeruginosa from upper and lower airways of cystic fibrosis patients.

    The European respiratory journal·2002
    Same journal

    Use of the polymerase chain reaction for the specific and direct detection of Clostridium difficile in human feces.

    Reviews of infectious diseases·1991
    Same journal

    Disseminated pelvic actinomycosis presenting as metastatic carcinoma: association with the progestasert intrauterine device.

    Reviews of infectious diseases·1991
    Same journal

    Genetically engineered attenuated herpes simplex viruses.

    Reviews of infectious diseases·1991
    Same journal

    Did scarlet fever and rheumatic fever exist in Hippocrates' time?

    Reviews of infectious diseases·1991
    Same journal

    Experimental infection of human subject with Strongyloides species.

    Reviews of infectious diseases·1991
    Same journal

    Seroepidemiology of pertussis in Italy.

    Reviews of infectious diseases·1991
    See all related articles

    Area of Science:

    • Microbiology
    • Enzymology
    • Biochemistry

    Background:

    • Traditional beta-lactamase classification relies on substrate activity.
    • Emerging beta-lactam structures require more specific enzyme profiling.
    • Nonchromosomal beta-lactamases present classification challenges.

    Purpose of the Study:

    • To review and update the classification of beta-lactamases from gram-positive and gram-negative organisms.
    • To incorporate new data on recently discovered beta-lactamases.
    • To explore integrating biophysical and sequence data for improved classification.

    Main Methods:

    • Review of existing literature and classification systems.
    • Inclusion of data on recently discovered beta-lactamases.
    • Emphasis on biophysical characterization, particularly isoelectric focusing.

    Related Experiment Videos

    Main Results:

    • The current classification system is being updated with new enzyme data.
    • Biophysical characterization has enhanced the classification of nonchromosomal beta-lactamases.
    • Future classification will integrate amino acid sequences and molecular structures.

    Conclusions:

    • Beta-lactamase classification requires adaptation to new enzyme types and data.
    • Biophysical methods and sequence analysis are key to refining classification.
    • Evolutionary perspectives will further enhance the established classification system.