Tissue-resident memory T cells in the kidney

The identification of tissue-resident memory T cells (T_RM cells) has significantly improved our understanding of immunity. In the last decade, studies have demonstrated that T_RM cells are induced after an acute T-cell response, remain in peripheral organs for several years, and contribute to both an efficient host defense and autoimmune disease. T_RM cells are found in the kidneys of healthy individuals and patients with various kidney diseases. A better understanding of these cells and their therapeutic targeting might provide new treatment options for infections, autoimmune diseases, graft rejection, and cancer. In this review, we address the definition, phenotype, and developmental mechanisms of T_RM cells. Then, we further discuss the current understanding of T_RM cells in kidney diseases, such as infection, autoimmune disease, cancer, and graft rejection after transplantation.