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Updated: Sep 27, 2025

Peptide-based Identification of Functional Motifs and their Binding Partners

Peptide-based Identification of Functional Motifs and their Binding Partners

Published on: June 30, 2013

Peptide-Based HIV Entry Inhibitors.

Jing Pu¹, Qian Wang¹, Shibo Jiang²

¹Key Laboratory of Medical Molecular Virology (MOE/NHC/CAMS), School of Basic Medical Sciences, Institute of Infectious Disease and Biosecurity, Fudan University, Shanghai, China.

Advances in Experimental Medicine and Biology

|April 12, 2022

Summary

This summary is machine-generated.

Peptide-based HIV entry inhibitors offer a vital therapeutic option for patients resistant to other treatments. Research continues to advance these drugs, targeting early viral infection stages.

Keywords:

6-HB Entry inhibitor HIV Lipopeptide Membrane fusion Peptide

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Area of Science:

Virology
Drug Discovery
Immunology

Background:

Peptide-based HIV entry inhibitors represent a significant advancement in anti-HIV therapeutics.
Approved drugs like enfuvirtide and albuvirtide target the early stages of HIV infection.
These inhibitors are crucial for patients with treatment-resistant HIV.

Purpose of the Study:

To review the historical development of peptide-based HIV entry inhibitors.
To discuss the current research landscape and clinical applications.
To explore future trends in the development of these antiviral agents.

Main Methods:

Literature review of published research on peptide-based HIV entry inhibitors.
Analysis of clinical trial data and drug approval processes.
Synthesis of information on mechanisms of action and resistance patterns.

Main Results:

Enfuvirtide (approved 2003) and albuvirtide (approved 2018) are key examples of successful peptide-based HIV entry inhibitors.
These drugs effectively block viral entry by inhibiting fusion between viral and host cell membranes.
They offer a valuable alternative for patients with multi-drug resistant HIV.

Conclusions:

Peptide-based HIV entry inhibitors are a critical component of HIV treatment, particularly for salvage therapy.
Continued research is essential to overcome resistance and develop next-generation inhibitors.
Future directions include exploring novel peptide designs and combination therapies.