Mechanisms of immunoregulation. Immunoregulation by antibody and antigen-antibody complexes

Biologically important regulatory mechanisms exist in many immune responses. The anatomic characteristics of lymphoid tissues and the cell-collaborative events exhibited in immune responses may be explicable in terms of potent regulatory phenomena rather than or as well as requirements for the initial activation of an immune response by antigen. Mechanistically, the regulatory web54 may be a series of Fc portion attachments to Fc receptors directed by the variable region specificities of the antibodies involved.