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A Thrombotic Stroke Model Based On Transient Cerebral Hypoxia-ischemia
06:01

A Thrombotic Stroke Model Based On Transient Cerebral Hypoxia-ischemia

Published on: August 18, 2015

Soluble TREM2 is associated with death and cardiovascular events after acute ischemic stroke: an observational study

Yaling Lu1, Yu Zhao2, Qi Zhang1

  • 1Department of Epidemiology, School of Public Health and Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Medical College of Soochow University, 199 Renai Road, Industrial Park District, Suzhou, 215123, Jiangsu, China.

Journal of Neuroinflammation
|April 13, 2022
PubMed
Abstract

Insights

Elevated soluble triggering receptor expressed on myeloid cells 2 (sTREM2) levels in acute ischemic stroke (AIS) patients are linked to higher risks of death and cardiovascular events. This biomarker may improve risk prediction after stroke.

Area of Science:

  • Neuroscience
  • Immunology
  • Cardiovascular Medicine

Background:

  • Soluble triggering receptor expressed on myeloid cells 2 (sTREM2) reflects microglia activation and is associated with neuroinflammation and neuronal injury.
  • Investigating plasma sTREM2 in acute ischemic stroke (AIS) patients is crucial for understanding post-stroke outcomes.

Purpose of the Study:

  • To prospectively examine the association between plasma sTREM2 levels and clinical outcomes in AIS patients.
  • To determine if sTREM2 improves risk prediction for adverse events following AIS.

Main Methods:

  • Plasma sTREM2 levels were measured in 3285 AIS patients from the China Antihypertensive Trial in Acute Ischemic Stroke.
  • Cox proportional hazards and logistic regression models assessed associations between sTREM2 and outcomes (death, cardiovascular events, severe disability) at 1-year follow-up.

Main Results:

  • Higher sTREM2 levels were associated with increased risks of death (HR 1.68; 95% CI 1.09-2.60) and a composite of death or cardiovascular events (HR 1.57; 95% CI 1.11-2.21).
  • sTREM2 incorporation improved risk prediction models for composite outcomes.
  • Joint elevation of sTREM2 and galectin-3 indicated the highest risk for death and cardiovascular events.

Conclusions:

  • Elevated plasma sTREM2 is an independent predictor of increased mortality and cardiovascular events after AIS.
  • sTREM2 may serve as a valuable biomarker for risk stratification in AIS patients.
Keywords:
Cardiovascular eventsDeathIschemic strokePrognosissTREM2

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