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Updated: Sep 27, 2025

The WATCHMAN Left Atrial Appendage Closure Device for Atrial Fibrillation
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The WATCHMAN Left Atrial Appendage Closure Device for Atrial Fibrillation

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[Modern issues of improving the prognosis in patients with atrial fibrillation after ischemic stroke]

O D Ostroumova1, T M Ostroumova2, A V Arablinsky3

  • 1Russian Medical Academy of Continuous Professional; I.M. Sechenov First Moscow State Medical University.

Kardiologiia
|April 13, 2022
PubMed

Insights

Direct oral anticoagulants like rivaroxaban are effective for preventing recurrent stroke in atrial fibrillation (AF) patients. Rivaroxaban offers advantages in efficacy, safety, and patient compliance for secondary stroke prevention.

Area of Science:

  • Cardiology
  • Neurology
  • Pharmacology

Background:

  • Atrial fibrillation (AF) increases stroke risk, necessitating effective anticoagulant therapy.
  • Direct oral anticoagulants (DOACs) are recommended for stroke prevention in AF.
  • Evidence supports rivaroxaban's efficacy and safety in secondary stroke prevention.

Purpose of the Study:

  • To evaluate the advantages of rivaroxaban for secondary stroke prevention in AF patients.
  • To assess rivaroxaban's role in improving prognosis through stroke prevention, kidney disease management, and atherosclerosis control.
  • To highlight rivaroxaban's benefits regarding patient compliance due to once-daily dosing.

Main Methods:

  • Review of extensive evidence-based databases comparing DOACs.
  • Analysis of clinical guidelines recommending anticoagulant therapy for AF.
  • Assessment of rivaroxaban's safety profile and impact on comorbidities.

Main Results:

  • Rivaroxaban demonstrates significant advantages over other DOACs in secondary stroke prevention for AF.
  • Rivaroxaban offers an optimal safety profile.
  • Benefits include stroke recurrence prevention, reduced kidney disease progression, and slowed vascular atherosclerosis.

Conclusions:

  • Rivaroxaban is a preferred choice for secondary stroke prevention in AF patients.
  • Its once-daily dosing improves compliance, especially in patients with cognitive disorders.
  • Rivaroxaban offers a favorable prognosis by addressing multiple aspects of AF-related complications.

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