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[The role of thrombin in the pathogenesis of atherosclerosis and its complications]

O A Dukhin1, A I Kalinsaya1, A V Shpektor2

  • 1A.I. Yevdokimov Moscow State University of Medicine and Dentistry; Moscow Clinical City Hospital named after I.V. Davydovsky.

Kardiologiia
|April 13, 2022
PubMed

Insights

Thrombin, a key regulator of homeostasis, significantly contributes to atherosclerosis and ischemic heart disease (IHD). Understanding thrombin

Area of Science:

  • Biochemistry
  • Cardiovascular Medicine
  • Hematology

Background:

  • Thrombin is a critical enzyme in hemostasis and thrombosis.
  • Thrombin plays a significant role in the pathogenesis of atherosclerosis and ischemic heart disease (IHD).
  • Existing data highlight thrombin's involvement in cardiovascular disease progression.

Purpose of the Study:

  • To review the mechanisms of thrombin functioning.
  • To elucidate thrombin's role in atherosclerosis development and progression.
  • To assess the clinical relevance of thrombin activity biomarkers in IHD patients.

Main Methods:

  • Literature review of experimental and clinical studies.
  • Analysis of major mechanisms of thrombin functioning.
  • Evaluation of available tests for thrombin functional activity.

Main Results:

  • Thrombin is implicated in the progression of atherosclerosis.
  • Clinical studies have investigated thrombin inhibitors and protease-activated receptor antagonists.
  • Biomarkers of thrombin activity may predict cardiovascular complications in IHD.

Conclusions:

  • Regulation of thrombin activity is a promising therapeutic target.
  • Further research is needed to validate thrombin activity biomarkers for IHD risk stratification.
  • Understanding thrombin's role is crucial for managing cardiovascular diseases.

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