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Updated: Sep 27, 2025

Monitoring Changes in Human Umbilical Vein Endothelial Cells upon Viral Infection Using Impedance-Based Real-Time Cell Analysis
Published on: May 5, 2023
[Pathophysiological basis and diagnosis of the cardiovascular system damage caused by coronavirus infection]
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Insights
Coronavirus infection can cause cardiovascular damage, including heart failure and arrhythmias. Early diagnosis and monitoring of clinical indicators are crucial for managing these cardiac complications.
Area of Science:
- Cardiology
- Infectious Diseases
- Pathophysiology
Background:
- Coronavirus disease 2019 (COVID-19) is associated with significant cardiovascular complications.
- Understanding the pathogenesis and clinical manifestations of cardiac injury in COVID-19 is critical.
Purpose of the Study:
- To review the pathogenesis, clinical manifestations, and diagnostic methods for cardiovascular damage in COVID-19.
- To highlight the importance of early diagnosis and monitoring for cardiovascular complications.
Main Methods:
- Literature search of Elsevier, PubMed, and Web of Science databases.
- Keywords used: COVID-19, myocarditis, coronavirus, myocardial injury.
- Review of studies on cardiovascular manifestations and diagnosis.
Main Results:
- COVID-19 can present with acute heart failure, myocardial injury, arrhythmias, pericarditis, venous thromboembolism, and microcirculatory dysfunction.
- Symptoms are often non-specific, necessitating close monitoring of clinical and laboratory parameters.
- Deviations from normal ranges warrant suspicion of cardiovascular complications.
Conclusions:
- Early differential diagnosis of cardiovascular disease is essential in COVID-19 patients.
- Prompt identification and assessment of cardiac and/or vascular injury are necessary.
- Development of comprehensive treatment and prevention strategies for cardiovascular complications is required.
Abstract:
This review focuses on the pathogenesis, most common clinical manifestations, and methods for diagnosis of damages to the cardiovascular system in coronavirus infection. The search for studies to be reviewed included publications of Elsevier, PubMed, and Web of Science resources by the key words "COVID-19", "myocarditis", "coronavirus", and "myocardial injury". The clinical presentation of coronavirus infection can include acute heart failure, myocardial injury, arrhythmias, pericarditis, venous thromboembolism, and microcirculatory dysfunction. Since symptoms of this pathology are non-specific, it is important to pay attention to monitoring of clinical laboratory and instrumental indexes for early differential diagnosis of cardiovascular disease. In all cases of parameter deviation from the normal range, cardiovascular complications of COVID-19 should be suspected. Measures should be taken for specifying the occurrence and severity of cardiac and/or vascular injury, and approaches should be developed for comprehensive treatment or prevention of these conditions.
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