Related Experiment Video

Updated: Jul 5, 2026

A Rapid, Multiplex Dual Reporter IgG and IgM SARS-CoV-2 Neutralization Assay for a Multiplexed Bead-Based Flow Analysis System
07:08

A Rapid, Multiplex Dual Reporter IgG and IgM SARS-CoV-2 Neutralization Assay for a Multiplexed Bead-Based Flow Analysis System

Published on: April 6, 2021

REGN-COV2 antibody cocktail in patients with SARS-CoV-2: Observational study from a single institution in Japan

Ayana Sakurai1, Shoko Marshall1, Tomoko Ogasawara1

  • 1Department of Medicine, Tokyo Women's Medical University Medical Center East, 2-1-10 Nishiogu, Arakawaku, Tokyo, 116-8567, Japan.

Journal of Infection and Chemotherapy : Official Journal of the Japan Society of Chemotherapy
|April 13, 2022
PubMed
Abstract

Insights

The REGN-COV2 antibody cocktail, a treatment for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), demonstrated safety and benefit in high-risk coronavirus disease (COVID-19) patients. This therapy reduced hospitalizations without observed adverse effects.

Area of Science:

  • Infectious Diseases
  • Immunology
  • Pharmacology

Background:

  • Coronavirus disease (COVID-19) poses a significant risk, particularly for individuals with comorbidities.
  • REGN-COV2, a neutralizing antibody cocktail targeting SARS-CoV-2, has received approval for at-risk patients.
  • Early intervention with effective treatments is crucial for managing severe COVID-19.

Purpose of the Study:

  • To evaluate the safety and efficacy of the REGN-COV2 antibody cocktail in patients with COVID-19 and risk factors for severe disease.
  • To assess COVID-19-related hospitalization rates, symptom duration, and adverse events following REGN-COV2 treatment.
  • To determine the clinical utility of this antibody cocktail in a real-world patient cohort.

Main Methods:

  • Retrospective review of 108 patients diagnosed with COVID-19 between July and September 2021.
  • REGN-COV2 administered within 7 days of symptom onset to patients with oxygen saturation >93% and at least one comorbidity.
  • Analysis of hospitalization, symptom duration, and adverse effects as primary outcome measures.

Main Results:

  • The patient cohort (n=108) had a high prevalence of risk factors, including age ≥50 (64%), obesity (31%), hypertension (36%), and diabetes (18%).
  • 11% of patients required COVID-19-related hospitalization.
  • No adverse effects associated with the REGN-COV2 antibody cocktail treatment were reported.

Conclusions:

  • The REGN-COV2 antibody cocktail is a safe therapeutic option for patients at risk of severe COVID-19.
  • Treatment with REGN-COV2 demonstrated a beneficial impact on clinical outcomes in this patient group.
  • The findings support the use of neutralizing antibody cocktails for managing high-risk COVID-19 cases.
Keywords:
CasirivimabImdevimabNeutralizing monoclonal antibodiesSARS-CoV-2

More Related Videos

Live Imaging and Quantification of Viral Infection in K18 hACE2 Transgenic Mice Using Reporter-Expressing Recombinant SARS-CoV-208:41

Live Imaging and Quantification of Viral Infection in K18 hACE2 Transgenic Mice Using Reporter-Expressing Recombinant SARS-CoV-2

Published on: November 5, 2021

Dynamic Monitoring of Seroconversion using a Multianalyte Immunobead Assay for Covid-1908:48

Dynamic Monitoring of Seroconversion using a Multianalyte Immunobead Assay for Covid-19

Published on: February 16, 2022

Related Concept Videos

Immunoprecipitation01:20

Immunoprecipitation

Immunoprecipitation, or IP, is a widely used technique that employs protein-antibody interactions to isolate proteins or protein complexes in their native state for studying protein-protein interactions, quaternary structures, or supramolecular complexes. Various modifications of the technique, including chromatin IP, cross-linking IP, and fluorescence IP, are commonly used.
Chromatin Immunoprecipitation
Chromatin immunoprecipitation, also known as ChIP, is used to study protein-DNA or...
Enzyme-Linked Immunosorbent Assay01:33

Enzyme-Linked Immunosorbent Assay

In 1971, Peter Perlman and Eva Engvall developed an Enzyme-linked immunosorbent assay (ELISA or EIA). ELISA differs from western blot in that the assays are conducted in microtiter plates or in vivo rather than on an absorbent membrane.
There are many different types of ELISAs, but they all involve an antibody molecule whose constant region binds an enzyme, leaving the variable region free to bind its specific antigen.  Enzyme-substrate reaction allows the antigen to be visualized or quantified.
Bioavailability Study Design: Healthy Subjects Versus Patients01:15

Bioavailability Study Design: Healthy Subjects Versus Patients

Bioavailability studies are essential for evaluating a drug's therapeutic efficacy and understanding its absorption patterns under various physiological conditions. Conducting such studies on target patient populations provides more relevant data by simulating real-world disease states. However, practical challenges often necessitate the use of young, healthy adult volunteers as study subjects.Patients may exhibit altered drug absorption patterns due to the effects of the disease itself,...
Cytomegalovirus Disease01:27

Cytomegalovirus Disease

Cytomegalovirus (CMV) disease is caused by human cytomegalovirus, a double-stranded DNA virus of the Herpesviridae family. While primary CMV infection is often asymptomatic in immunocompetent individuals, the virus can cause severe disease in neonates and immunocompromised patients. CMV is the most common cause of congenital viral infection in the United States, and a major pathogen in solid organ and hematopoietic stem cell transplant recipients.CMV is transmitted via bodily fluids, sexual...
Coronavirus01:29

Coronavirus

Coronaviruses, including the severe acute respiratory syndrome coronavirus (SARS-CoV), are enveloped viruses characterized by their single-stranded, positive-sense RNA genome and helical nucleocapsid structure. The hallmark of these viruses is their club-shaped spike (S) glycoproteins that protrude from the viral envelope, facilitating attachment to host cells. Typically, coronaviruses infect the upper respiratory tract, often causing mild or asymptomatic disease. However, certain strains like...
Respiratory Syncytial Virus Disease01:29

Respiratory Syncytial Virus Disease

Human respiratory syncytial virus (RSV) is a widespread pathogen that primarily targets infants and young children but also poses a serious health risk to elderly and immunocompromised individuals. Belonging to the Pneumoviridae family, RSV is a negative-sense, single-stranded RNA virus within the Pneumovirus genus. Its global health burden is significant, with millions of cases annually resulting in hospitalizations and mortality, particularly in resource-limited settings. Although most...