Related Experiment Video

Updated: Sep 27, 2025

Measuring the Carotid to Femoral Pulse Wave Velocity Cf-PWV to Evaluate Arterial Stiffness
05:51

Measuring the Carotid to Femoral Pulse Wave Velocity Cf-PWV to Evaluate Arterial Stiffness

Published on: May 3, 2018

17.8K

Covid-19 Effects on ARTErial StIffness and Vascular AgeiNg: CARTESIAN Study Rationale and Protocol

Rosa Maria Bruno1, Bart Spronck2,3, Bernhard Hametner4

  • 1INSERM U970 Team 7, Paris Cardiovascular Research Centre - PARCC, University Paris Descartes, AP-HP, Pharmacology Unit, Hôpital Européen Georges Pompidou, 56 Rue Leblanc, Paris 75015, France.

Artery Research
|April 13, 2022
PubMed

Insights

The CARTESIAN study investigates how COVID-19 impacts vascular ageing, assessing early vascular ageing (EVA) markers six and twelve months post-infection. This research aims to understand COVID-19

Area of Science:

  • Cardiovascular Medicine
  • Infectious Diseases
  • Vascular Biology
  • Epidemiology

Background:

  • COVID-19, a novel coronavirus pneumonia, has caused a global pandemic since December 2019.
  • While primarily respiratory, COVID-19 significantly affects the cardiovascular system.
  • The long-term vascular consequences of COVID-19 remain largely uncharacterized.

Purpose of the Study:

  • To evaluate the presence of Early Vascular Ageing (EVA) 6 and 12 months after COVID-19 infection.
  • To assess the impact of COVID-19 disease severity on EVA.
  • To explore the influence of psychosocial factors, comorbidities, and treatments on COVID-19-induced EVA.

Main Methods:

  • The CARTESIAN study is the first international multicentre initiative on COVID-19's effects on vascular ageing biomarkers.
  • Utilizes non-invasive cardiovascular measurements: carotid-femoral pulse wave velocity, central blood pressure, carotid ultrasound, and brachial flow-mediated dilatation.
  • Enrolls over 2500 individuals across 43 centers in 21 countries.

Main Results:

  • This section is to be filled upon study completion.

Conclusions:

  • The CARTESIAN study will provide novel insights into the relationship between COVID-19, disease severity, and early vascular ageing.
  • Findings may inform future diagnostic and care strategies, focusing on vulnerable populations.
  • Establishes a large cohort for understanding post-COVID-19 vascular health.

Keywords:
COVID-19arterial stiffnesscoronavirusinflammationvascular ageing

More Related Videos

Measuring Ascending Aortic Stiffness In Vivo in Mice Using Ultrasound10:08

Measuring Ascending Aortic Stiffness In Vivo in Mice Using Ultrasound

Published on: December 2, 2014

16.2K
Measuring the Stiffness of Ex Vivo Mouse Aortas Using Atomic Force Microscopy10:35

Measuring the Stiffness of Ex Vivo Mouse Aortas Using Atomic Force Microscopy

Published on: October 19, 2016

10.7K

Related Concept Videos

Atherosclerosis II: Clinical Manifestations and Diagnostic Tests01:27

Atherosclerosis II: Clinical Manifestations and Diagnostic Tests

Atherosclerosis is a progressive disorder that leads to the thickening and narrowing of arterial walls due to plaque buildup. This condition can cause various symptoms depending on the arteries affected:Coronary Artery Disease (CAD): This condition affects the coronary arteries and may lead to chest pain (angina), shortness of breath (dyspnea), heart attacks, and other heart disease symptoms.Cerebrovascular Disease: This affects blood flow to the brain, causing transient ischemic attacks (TIAs)...
59
Coronary Artery Disease I: Introduction01:30

Coronary Artery Disease I: Introduction

Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
99
Atherosclerosis I: Introduction01:30

Atherosclerosis I: Introduction

Atherosclerosis is a progressive disorder characterized by the buildup of plaques on the arterial inner wall, causing them to narrow and harden over time. These plaques comprise lipids, calcium, blood components, carbohydrates, and fibrous tissue. The process primarily affects the intima of large and medium-sized arteries, reducing blood flow in any artery.Etiology and risk factorsThe cause of atherosclerosis is multifactorial, involving a complex interplay among endothelial injury, lipid...
132
Atherosclerosis III: Management01:26

Atherosclerosis III: Management

Management of atherosclerosis involves an integrated strategy encompassing pharmacological treatment, surgical interventions, lifestyle changes, and nutrition therapy to address the multifactorial nature of the disease.Pharmacological TherapyA cornerstone of atherosclerosis management is the use of pharmacological agents. Statins, such as atorvastatin, are pivotal in inhibiting HMG-CoA reductase, an enzyme that catalyzes an initial step in cholesterol synthesis in the liver. This reduction in...
54
The Effect of Aging on Tissues01:19

The Effect of Aging on Tissues

Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
2.7K
Peripheral Artery Disease I: Introduction01:30

Peripheral Artery Disease I: Introduction

Peripheral artery disease (PAD) predominantly results from atherosclerosis, which involves the accumulation of fatty deposits, or plaques, within the walls of arteries. This causes them to narrow and harden, significantly reducing blood flow. PAD predominantly affects the legs, particularly the arteries supplying the thighs and calves. In rare cases, it may involve other arteries, including those in the arms.Etiology of PAD:The principal cause of PAD is atherosclerosis, which results from fatty...
53