Consolidative opacity in a patient with acute leukemia
Chaitra Banala1, William P Brasher2, Rashmi Kanagal Shamanna3
1Department of Internal Medicine Baylor College of Medicine Houston Texas USA.
Clinical Case Reports
|April 13, 2022
Summary
A 27-year-old man with acute myeloid leukemia experienced parenchymal consolidation, diagnosed as myeloid sarcoma. Hematopoietic stem cell transplantation led to the resolution of this consolidation.
Area of Science:
- Hematology
- Oncology
Background:
- Acute myeloid leukemia (AML) can present with extramedullary manifestations.
- Myeloid sarcoma is a rare extramedullary tumor of myeloid blasts.
Purpose of the Study:
- To report a case of newly diagnosed acute myeloid leukemia presenting with parenchymal consolidation suggestive of myeloid sarcoma.
- To highlight the diagnostic challenges and treatment outcomes.
Main Methods:
- Clinical presentation and diagnostic imaging were reviewed.
- Diagnostic studies, though not including biopsy, supported the diagnosis of myeloid sarcoma.
- Treatment response was assessed after hematopoietic stem cell transplantation.
Main Results:
- The patient, a 27-year-old male, was diagnosed with acute myeloid leukemia.
- New parenchymal consolidation was observed, presumed to be myeloid sarcoma.
- Complete resolution of the consolidation was achieved following hematopoietic stem cell transplantation.
Conclusions:
- Myeloid sarcoma can manifest as parenchymal consolidation in acute myeloid leukemia.
- Hematopoietic stem cell transplantation is an effective treatment for myeloid sarcoma in AML.
- Multidisciplinary diagnostic approaches are crucial when biopsy is not feasible.
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